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Akr1c18 Gene Detail
Summary
  • Symbol
    Akr1c18
  • Name
    aldo-keto reductase family 1, member C18
  • Synonyms
    20alpha-HSD, 20alpha-hydroxysteroid dehydrogenase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145420
    NCBI Gene: 105349
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:4182614-4200645 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 2.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    464 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145420
 protein coding gene Chr13:4182614-4200653 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020203
 protein coding gene Chr13:617076-634881 (-)
A/J MGP_AJ_G0020159
 protein coding gene Chr13:709708-727570 (-)
AKR/J MGP_AKRJ_G0020134
 protein coding gene Chr13:730425-748469 (-)
BALB/cJ MGP_BALBcJ_G0020142
 protein coding gene Chr13:708095-726102 (-)
C3H/HeJ MGP_C3HHeJ_G0019946
 protein coding gene Chr13:794190-812211 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020589
 protein coding gene Chr13:687467-705424 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018201
 protein coding gene Chr13:613642-631746 (-)
CAST/EiJ MGP_CASTEiJ_G0019486
 protein coding gene Chr13:633726-651597 (-)
CBA/J MGP_CBAJ_G0019913
 protein coding gene Chr13:700155-718150 (-)
DBA/2J MGP_DBA2J_G0020030
 protein coding gene Chr13:627858-645642 (-)
FVB/NJ MGP_FVBNJ_G0020015
 protein coding gene Chr13:599280-617302 (-)
LP/J MGP_LPJ_G0020104
 protein coding gene Chr13:683350-701272 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020051
 protein coding gene Chr13:757644-775306 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020617
 protein coding gene Chr13:681534-699444 (-)
PWK/PhJ MGP_PWKPhJ_G0019248
 protein coding gene Chr13:691087-709438 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019053
 protein coding gene Chr13:724580-742560 (-)
WSB/EiJ MGP_WSBEiJ_G0019544
 protein coding gene Chr13:632390-650406 (-)



Homology
more
  • Human Ortholog
    AKR1C3, aldo-keto reductase family 1 member C3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKR1C3, aldo-keto reductase family 1 member C3
  • Synonyms
    DD3, DDX, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, PGFS
  • Links
    NCBI Gene ID: 8644
    neXtProt AC: NX_P42330
    UniProt: P42330

  • Chr Location
    10p15.1; chr10:5035354-5107686 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human AKR1C2,AKR1C3,AKR1C4 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations in this gene display prolonged pregnancies and decreased number of pups. Some cannot induce parturition while others are able to give birth but show a prolonged estrous cycle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    862
  • Tissues
    111
  • cDNA Data
    18
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 105349 NCBI Gene Model | MGI Sequence Detail 18032 C57BL/6J ±  kb
    transcript NM_134066 RefSeq | MGI Sequence Detail 1199 C57BL/6  
    polypeptide Q8K023 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 18
      Primer pair 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 17
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:82195 Vergnes L, et al., A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. J Lipid Res. 2003 Mar;44(3):503-11
    • Latest
      J:349748 Shi T, et al., Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F(2alpha) (PGF(2alpha)) levels. Biochem Pharmacol. 2024 Jul;225:116309
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory