Ipo13 MGI Mouse Gene Detail - MGI:2385205

Symbol

Ipo13
Name

importin 13
Synonyms

Imp13, Kap13

Feature Type

protein coding gene
IDs

MGI:2385205
NCBI Gene: 230673
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr4:117751683-117772196 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 53.76 cM
Mapping Data

2 experiments

SNPs within 2kb

442 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385205	protein coding gene	Chr4:117751683-117772419 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028660	protein coding gene	Chr4:118898734-118919859 (-)
A/J	MGP_AJ_G0028621	protein coding gene	Chr4:114311982-114335091 (-)
AKR/J	MGP_AKRJ_G0028571	protein coding gene	Chr4:116818443-116838587 (-)
BALB/cJ	MGP_BALBcJ_G0028642	protein coding gene	Chr4:114950533-114970719 (-)
C3H/HeJ	MGP_C3HHeJ_G0028356	protein coding gene	Chr4:118393622-118413664 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029083	protein coding gene	Chr4:123477126-123497181 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026367	protein coding gene	Chr4:108340515-108360770 (-)
CAST/EiJ	MGP_CASTEiJ_G0027790	protein coding gene	Chr4:115620056-115640246 (-)
CBA/J	MGP_CBAJ_G0028323	protein coding gene	Chr4:126845117-126865303 (-)
DBA/2J	MGP_DBA2J_G0028471	protein coding gene	Chr4:114929842-114949852 (-)
FVB/NJ	MGP_FVBNJ_G0028439	protein coding gene	Chr4:113444920-113465303 (-)
LP/J	MGP_LPJ_G0028573	protein coding gene	Chr4:119085875-119107797 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028466	protein coding gene	Chr4:131766195-131786339 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029120	protein coding gene	Chr4:117962668-117984095 (-)
PWK/PhJ	MGP_PWKPhJ_G0027516	protein coding gene	Chr4:111750078-111770336 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027339	protein coding gene	Chr4:114277238-114297544 (-)
WSB/EiJ	MGP_WSBEiJ_G0027869	protein coding gene	Chr4:117844455-117864595 (-)

Human Ortholog

IPO13, importin 13

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IPO13, importin 13
Synonyms

IMP13, KAP13, LGL2, RANBP13
Links

HGNC:16853

NCBI Gene ID: 9670

neXtProt AC: NX_O94829

UniProt: O94829
Chr Location

1p34.1; chr1:43946950-43968022 (+) GRCh38

MGI Vertebrate Homology

Ipo13 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: IPO13
Gene Tree

Ipo13

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Gene trapped

2
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Ipo13
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available

Mice homozygous for a gene trap insertion die prior to genotyping age.

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

865
Tissues

37
cDNA Data

90
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ipo13

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All Sequences

59
RefSeq

8
UniProt

2
CCDS

CCDS18542.1

Ensembl

ENSMUSG00000033365 (Evidence)
NCBI Gene

230673

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033365	Ensembl Gene Model \| MGI Sequence Detail	20514	C57BL/6J	± kb
transcript	ENSMUST00000036156	Ensembl \| MGI Sequence Detail	3595	Not Applicable
polypeptide	ENSMUSP00000035989	Ensembl \| MGI Sequence Detail	963	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009086 importin-13

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR013598 Exportin-1/Importin-beta-like

IPR040520 Importin 13 repeat

IPR040709 Importin 13, repeat 1

IPR040944 Importin 13 repeat 2

IPR051345 Importin beta-like nuclear transport receptors

IPR001494 Importin-beta, N-terminal domain

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All nucleic 93

cDNA 91

Primer pair 2

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 12
Earliest

J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
Latest

J:327286 Gajewska KA, et al., Nuclear Transporter IPO13 Is Central to Efficient Neuronal Differentiation. Cells. 2022 Jun 12;11(12)

TSS for Ipo13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43015	Chr4:117772390-117772395 (-)	-197 bp
Tssr43014	Chr4:117772326-117772372 (-)	-153 bp
Tssr43013	Chr4:117772233-117772251 (-)	-46 bp
Tssr43012	Chr4:117772165-117772215 (-)	6 bp
Tssr43011	Chr4:117772137-117772154 (-)	50 bp
Tssr43010	Chr4:117771898-117771909 (-)	292 bp
Tssr43009	Chr4:117761785-117761812 (-)	10,397 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24