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Taf10 Gene Detail
Summary
  • Symbol
    Taf10
  • Name
    TATA-box binding protein associated factor 10
  • Synonyms
    30kDa, Taf2h, TAFII30
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346320
    NCBI Gene: 24075
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:105392101-105393550 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 55.97 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    89 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346320
 protein coding gene Chr7:105388600-105393568 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032763
 protein coding gene Chr7:109008669-109013637 (-)
A/J MGP_AJ_G0032743
 protein coding gene Chr7:106159333-106164301 (-)
AKR/J MGP_AKRJ_G0032676
 protein coding gene Chr7:108925953-108930921 (-)
BALB/cJ MGP_BALBcJ_G0032749
 protein coding gene Chr7:105867854-105872822 (-)
C3H/HeJ MGP_C3HHeJ_G0032458
 protein coding gene Chr7:109033479-109038447 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033254
 protein coding gene Chr7:113369132-113374100 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030238
 protein coding gene Chr7:108126585-108131571 (-)
CAST/EiJ MGP_CASTEiJ_G0031788
 protein coding gene Chr7:100863433-100868644 (-)
CBA/J MGP_CBAJ_G0032432
 protein coding gene Chr7:117141830-117149414 (-)
DBA/2J MGP_DBA2J_G0032585
 protein coding gene Chr7:104419511-104424479 (-)
FVB/NJ MGP_FVBNJ_G0032538
 protein coding gene Chr7:104227462-104232430 (-)
LP/J MGP_LPJ_G0032676
 protein coding gene Chr7:110414782-110419750 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032570
 protein coding gene Chr7:118718987-118726955 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033275
 protein coding gene Chr7:107996789-108004856 (-)
PWK/PhJ MGP_PWKPhJ_G0031501
 protein coding gene Chr7:97360583-97365764 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031350
 protein coding gene Chr7:95106805-95112703 (-)
WSB/EiJ MGP_WSBEiJ_G0031905
 protein coding gene Chr7:108634131-108639661 (-)



Homology
more
  • Human Ortholog
    TAF10, TATA-box binding protein associated factor 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAF10, TATA-box binding protein associated factor 10
  • Synonyms
    TAF2A, TAF2H, TAFII30
  • Links
    NCBI Gene ID: 6881
    neXtProt AC: NX_Q12962
    UniProt: Q12962

  • Chr Location
    11p15.4; chr11:6606294-6612539 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die shortly after implantation. Embryos are developmentally retarded and disorganized, the inner cell mass is small and trophoblasts stop endocycling. Ablation in keratinocytes during fetal development, but not in adult keratinocytes, results in impaired skin barrier function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    76
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    56
  • cDNA Data
    8
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24075 NCBI Gene Model | MGI Sequence Detail 1450 C57BL/6J ±  kb
    transcript NM_020024 RefSeq | MGI Sequence Detail 762 C57BL/6  
    polypeptide Q8K0H5 UniProt | EBI | MGI Sequence Detail 218 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000016015 transcription initiation factor TFIID subunit 10
      (term hierarchy)
    • InterPro Domains
      IPR003923 Transcription initiation factor TFIID, 23-30kDa subunit
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 8
      Primer pair 2
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143756
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 13
      Gene Ontology 18
      Phenotypes 20
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:337771 El-Saafin F, et al., Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. Cell Death Differ. 2022 May;29(5):1013-1027
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory