Acsm2 MGI Mouse Gene Detail - MGI:2385289 - acyl-CoA synthetase medium-chain family member 2

Symbol

Acsm2
Name

acyl-CoA synthetase medium-chain family member 2

Feature Type

protein coding gene
IDs

MGI:2385289
NCBI Gene: 233799
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:119153563-119199913 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 63.97 cM
Mapping Data

1 experiment

SNPs within 2kb

976 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385289	protein coding gene	Chr7:119153563-119199917 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032913	protein coding gene	Chr7:123456979-123509585 (+)
A/J	MGP_AJ_G0032896	protein coding gene	Chr7:120279020-120326215 (+)
AKR/J	MGP_AKRJ_G0032828	protein coding gene	Chr7:123381747-123428554 (+)
BALB/cJ	MGP_BALBcJ_G0032901	protein coding gene	Chr7:120006595-120053249 (+)
C3H/HeJ	MGP_C3HHeJ_G0032611	protein coding gene	Chr7:123266873-123319257 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033407	protein coding gene	Chr7:128354240-128407736 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030379	protein coding gene	Chr7:121715410-121768534 (+)
CAST/EiJ	MGP_CASTEiJ_G0031939	protein coding gene	Chr7:115033191-115084580 (+)
CBA/J	MGP_CBAJ_G0032584	protein coding gene	Chr7:132634633-132681055 (+)
DBA/2J	MGP_DBA2J_G0032736	protein coding gene	Chr7:118321125-118368559 (+)
FVB/NJ	MGP_FVBNJ_G0032689	protein coding gene	Chr7:118167233-118213598 (+)
LP/J	MGP_LPJ_G0032830	protein coding gene	Chr7:124929567-124979508 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032721	protein coding gene	Chr7:134106570-134165641 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033427	protein coding gene	Chr7:122352440-122400193 (+)
PWK/PhJ	MGP_PWKPhJ_G0031647	protein coding gene	Chr7:111238620-111286479 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031493	protein coding gene	Chr7:109106962-109154322 (+)
WSB/EiJ	MGP_WSBEiJ_G0032052	protein coding gene	Chr7:123257793-123307411 (+)

Human Ortholog

ACSM2A, acyl-CoA synthetase medium chain family member 2A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACSM2A, acyl-CoA synthetase medium chain family member 2A
Synonyms

A-923A4.1, ACSM2
Links

HGNC:32017

NCBI Gene ID: 123876

neXtProt AC: NX_Q08AH3

UniProt: Q08AH3
Chr Location

16p12.3; chr16:20451461-20487669 (+) GRCh38

Human Ortholog

ACSM2B, acyl-CoA synthetase medium chain family member 2B
Synonyms

ACSM2, HXMA, HYST1046
Links

HGNC:30931

NCBI Gene ID: 348158

neXtProt AC: NX_Q68CK6

UniProt: Q68CK6
Chr Location

16p12.3; chr16:20536226-20576427 (-) GRCh38

MGI Vertebrate Homology

Acsm2 stringent orthology
2 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ACSM2A, ACSM2B
Gene Tree

Acsm2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

859
Tissues

142
cDNA Data

338
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

69
RefSeq

6
UniProt

7
CCDS

CCDS21782.1, CCDS52379.1, CCDS52380.1

Ensembl

ENSMUSG00000030945 (Evidence)
NCBI Gene

233799

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030945	Ensembl Gene Model \| MGI Sequence Detail	46351	C57BL/6J	± kb
transcript	ENSMUST00000098084	Ensembl \| MGI Sequence Detail	2099	Not Applicable
polypeptide	ENSMUSP00000095690	Ensembl \| MGI Sequence Detail	600	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000004548 acyl-coenzyme A synthetase ACSM2, mitochondrial

(term hierarchy)
EC

6.2.1.2, 6.2.1.25
InterPro Domains

IPR020845 AMP-binding, conserved site

IPR025110 AMP-binding enzyme, C-terminal domain

IPR045851 AMP-binding enzyme, C-terminal domain superfamily

IPR000873 AMP-dependent synthetase/ligase domain

IPR042099 ANL, N-terminal domain

IPR051087 Mitochondrial Acyl-CoA Synthetase Medium-Chain

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All nucleic 338

cDNA 338

Microarray probesets 7

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MGI:2141900

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 7
Earliest

J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acsm2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68741	Chr7:119160922-119160949 (+)	7,373 bp
Tssr68742	Chr7:119180153-119180157 (+)	26,592 bp
Tssr68743	Chr7:119195258-119195268 (+)	41,700 bp
Tssr68744	Chr7:119195337-119195344 (+)	41,778 bp
Tssr68745	Chr7:119195988-119195993 (+)	42,428 bp
Tssr2387	Chr7:119196480-119196487 (+)	42,921 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24