About   Help   FAQ
Dph3 Gene Detail
Summary
  • Symbol
    Dph3
  • Name
    diphthamine biosynthesis 3
  • Synonyms
    2610018L09Rik, 5730511P15Rik, DELGIP1, DESR1, KTI11, Zcsl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922658
    NCBI Gene: 105638
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:31802523-31807686 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    250 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922658
 protein coding gene Chr14:31802474-31807686 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021136
 protein coding gene Chr14:25307643-25312768 (-)
A/J MGP_AJ_G0021084
 protein coding gene Chr14:24343372-24348498 (-)
AKR/J MGP_AKRJ_G0021061
 protein coding gene Chr14:25477760-25482886 (-)
BALB/cJ MGP_BALBcJ_G0021088
 protein coding gene Chr14:24500219-24505345 (-)
C3H/HeJ MGP_C3HHeJ_G0020871
 protein coding gene Chr14:25361656-25366782 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021520
 protein coding gene Chr14:26306975-26312101 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019083
 protein coding gene Chr14:24417217-24430635 (-)
CAST/EiJ MGP_CASTEiJ_G0020396
 protein coding gene Chr14:25156223-25161327 (-)
CBA/J MGP_CBAJ_G0020838
 protein coding gene Chr14:27297393-27302519 (-)
DBA/2J MGP_DBA2J_G0020960
 protein coding gene Chr14:24381758-24386884 (-)
FVB/NJ MGP_FVBNJ_G0020944
 protein coding gene Chr14:24337428-24342554 (-)
LP/J MGP_LPJ_G0021029
 protein coding gene Chr14:25630288-25635413 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020970
 protein coding gene Chr14:26539500-26544626 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021553
 protein coding gene Chr14:25260227-25265353 (-)
PWK/PhJ MGP_PWKPhJ_G0020144
 protein coding gene Chr14:23850473-23855742 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019968
 protein coding gene Chr14:24872372-24877486 (-)
WSB/EiJ MGP_WSBEiJ_G0020451
 protein coding gene Chr14:25327720-25332846 (-)



Homology
more
  • Human Ortholog
    DPH3, diphthamide biosynthesis 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPH3, diphthamide biosynthesis 3
  • Synonyms
    DELGIP, DELGIP1, DESR1, DPH3A, KTI11, ZCSL2
  • Links
    NCBI Gene ID: 285381
    neXtProt AC: NX_Q96FX2
    UniProt: Q96FX2

  • Chr Location
    3p25.1; chr3:16257061-16264969 (-)  GRCh38
  • Human Ortholog
    DPH3P1, diphthamide biosynthesis 3 pseudogene 1
  • Synonyms
    C20orf143, DPH3B, ZCSL1
  • Links
    NCBI Gene ID: 100132911
    neXtProt AC: NX_Q9H4G8
    UniProt: Q9H4G8

  • Chr Location
    20q13.33; chr20:62845597-62846191 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during organogenesis, failure of chorioallantoic fusion, impaired placental development, and embryonic growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    77
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021905 Ensembl Gene Model | MGI Sequence Detail 5164 C57BL/6J ±  kb
    transcript ENSMUST00000022461 Ensembl | MGI Sequence Detail 1057 Not Applicable  
    polypeptide ENSMUSP00000022461 Ensembl | MGI Sequence Detail 82 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 77

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917878, MGI:2145713, MGI:2145777
    References
    more
    • Summaries
      All 37
      Gene Ontology 9
      Phenotypes 6
    • Earliest
      J:354361 Moehring JM, et al., The post-translational trimethylation of diphthamide studied in vitro. J Biol Chem. 1988 Mar 15;263(8):3840-4
    • Latest
      J:354415 Cina DP, et al., Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion. Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1593-F1604
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory