Nfatc4 MGI Mouse Gene Detail - MGI:1920431 - nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4

Symbol

Nfatc4
Name

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4
Synonyms

3110041H08Rik

Feature Type

protein coding gene
IDs

MGI:1920431
NCBI Gene: 73181
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:56062252-56071400 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.19 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

255 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920431	protein coding gene	Chr14:56060601-56071400 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021373	protein coding gene	Chr14:49875410-49884425 (+)
A/J	MGP_AJ_G0021332	protein coding gene	Chr14:48870172-48879321 (+)
AKR/J	MGP_AKRJ_G0021308	protein coding gene	Chr14:50633312-50642943 (+)
BALB/cJ	MGP_BALBcJ_G0021336	protein coding gene	Chr14:48846352-48855502 (+)
C3H/HeJ	MGP_C3HHeJ_G0021116	protein coding gene	Chr14:50317043-50326195 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021774	protein coding gene	Chr14:52369945-52379082 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019321	protein coding gene	Chr14:47234858-47243940 (+)
CAST/EiJ	MGP_CASTEiJ_G0020635	protein coding gene	Chr14:46569922-46579029 (+)
CBA/J	MGP_CBAJ_G0021083	protein coding gene	Chr14:53935912-53945046 (+)
DBA/2J	MGP_DBA2J_G0021204	protein coding gene	Chr14:48588670-48597796 (+)
FVB/NJ	MGP_FVBNJ_G0021186	protein coding gene	Chr14:48039369-48048488 (+)
LP/J	MGP_LPJ_G0021278	protein coding gene	Chr14:50915138-50924221 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021210	protein coding gene	Chr14:53291312-53300428 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021801	protein coding gene	Chr14:49810953-49820150 (+)
PWK/PhJ	MGP_PWKPhJ_G0020382	protein coding gene	Chr14:45128454-45137753 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020210	protein coding gene	Chr14:45805984-45814969 (+)
WSB/EiJ	MGP_WSBEiJ_G0020688	protein coding gene	Chr14:50089777-50098864 (+)

Human Ortholog

NFATC4, nuclear factor of activated T cells 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NFATC4, nuclear factor of activated T cells 4
Synonyms

NF-AT3, NFAT3, NF-ATC4
Links

HGNC:7778

NCBI Gene ID: 4776

neXtProt AC: NX_Q14934

UniProt: Q14934
Chr Location

14q12; chr14:24365673-24379604 (+) GRCh38

MGI Vertebrate Homology

Nfatc4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NFATC4
Gene Tree

Nfatc4

Diseases

1 with human NFATC4 associations

				Human Disease	Mouse Models
				dilated cardiomyopathy IDs dilated cardiomyopathy DOID:12930 EFO:0000407 ICD10CM:I42.0 KEGG:05414 MESH:D002311 NCI:C84673 OMIM:PS115200 ORDO:217604 UMLS_CUI:C0007193

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
39 phenotypes from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Nfatc4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and overtly normal and exhibit normal embryonic heart morphology as well as normal pathophysiologic cardiac hypertrophy in response to angiotensin II infusion or aortic banding.

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All GO Annotations

71
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

870
Tissues

127
cDNA Data

48
Literature Summary

31

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN nfatc4

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All Sequences

64
RefSeq

4
UniProt

6
CCDS

CCDS27132.1, CCDS49500.1

Ensembl

ENSMUSG00000023411 (Evidence)
NCBI Gene

73181

			Length	Strain/Species	Flank
genomic	73181	NCBI Gene Model \| MGI Sequence Detail	9149	C57BL/6J	± kb
transcript	NM_001168346	RefSeq \| MGI Sequence Detail	4036	C57BL/6
polypeptide	Q8K120	UniProt \| EBI \| MGI Sequence Detail	901	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000011167 nuclear factor of activated T-cells, cytoplasmic 4

(term hierarchy)
InterPro Domains

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR002909 IPT domain

IPR008366 Nuclear factor of activated T cells (NFAT)

IPR008967 p53-like transcription factor, DNA-binding domain superfamily

IPR032397 Rel homology dimerisation domain

IPR011539 Rel homology domain, DNA-binding domain

IPR037059 Rel homology domain (RHD), DNA-binding domain superfamily

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All nucleic 51

cDNA 48

Primer pair 2

Other 1

Microarray probesets 5

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MGI:2145795, MGI:2145827

Summaries

All 105

Developmental Gene Expression 31

Diseases 1

Gene Ontology 22

Phenotypes 25
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nfatc4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125820	Chr14:56062318-56062346 (+)	80 bp
Tssr125821	Chr14:56062362-56062376 (+)	117 bp
Tssr125822	Chr14:56062401-56062420 (+)	159 bp
Tssr125823	Chr14:56062426-56062468 (+)	195 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24