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Tmem41b Gene Detail
Summary
  • Symbol
    Tmem41b
  • Name
    transmembrane protein 41B
  • Synonyms
    1500015G02Rik, 1500031M19Rik, D7Ertd70e, D7Ertd743e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289225
    NCBI Gene: 233724
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:109571394-109586136 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 57.69 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    518 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289225
 protein coding gene Chr7:109570422-109586136 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032851
 protein coding gene Chr7:113430822-113446487 (-)
A/J MGP_AJ_G0032835
 protein coding gene Chr7:110621732-110634165 (-)
AKR/J MGP_AKRJ_G0032766
 protein coding gene Chr7:113403171-113418425 (-)
BALB/cJ MGP_BALBcJ_G0032839
 protein coding gene Chr7:110318329-110332446 (-)
C3H/HeJ MGP_C3HHeJ_G0032549
 protein coding gene Chr7:113430426-113449631 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033345
 protein coding gene Chr7:118133815-118150839 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030318
 protein coding gene Chr7:112191925-112209445 (-)
CAST/EiJ MGP_CASTEiJ_G0031877
 protein coding gene Chr7:104967988-104984136 (-)
CBA/J MGP_CBAJ_G0032522
 protein coding gene Chr7:121992796-122012809 (-)
DBA/2J MGP_DBA2J_G0032674
 protein coding gene Chr7:108727357-108743196 (-)
FVB/NJ MGP_FVBNJ_G0032627
 protein coding gene Chr7:108581261-108597897 (-)
LP/J MGP_LPJ_G0032768
 protein coding gene Chr7:114961316-114978072 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032659
 protein coding gene Chr7:123652467-123673402 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033366
 protein coding gene Chr7:112410131-112426173 (-)
PWK/PhJ MGP_PWKPhJ_G0031584
 protein coding gene Chr7:101538088-101553868 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031432
 protein coding gene Chr7:99113867-99130516 (-)
WSB/EiJ MGP_WSBEiJ_G0031990
 protein coding gene Chr7:113259559-113274869 (-)



Homology
more
  • Human Ortholog
    TMEM41B, transmembrane protein 41B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM41B, transmembrane protein 41B
  • Links
    NCBI Gene ID: 440026
    neXtProt AC: NX_Q5BJD5
    UniProt: Q5BJD5

  • Chr Location
    11p15.4; chr11:9280654-9314636 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit embryonic growth arrest and complete embryonic lethality between implantation and placentation. Mice heterozygous for a null allele display reduced serum lipid levels, impaired autophagic flux, and resistance to coronavirus infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    2
  • cDNA Data
    33
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047554 Ensembl Gene Model | MGI Sequence Detail 14743 C57BL/6J ±  kb
    transcript ENSMUST00000094097 Ensembl | MGI Sequence Detail 3840 Not Applicable  
    polypeptide ENSMUSP00000091641 Ensembl | MGI Sequence Detail 291 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 34
      Primer pair 3

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:1098618, MGI:1916268, MGI:1923591, MGI:2143199
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:347623 Carlini MJ, et al., Stasimon/Tmem41b is required for cell proliferation and adult mouse survival. Biochem Biophys Res Commun. 2024 Apr 16;712-713:149923
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory