Stx5a MGI Mouse Gene Detail - MGI:1928483

Symbol

Stx5a
Name

syntaxin 5A
Synonyms

0610031F24Rik, D19Ertd627e, syntaxin 5

Feature Type

protein coding gene
IDs

MGI:1928483
NCBI Gene: 56389
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:8718788-8733006 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 5.45 cM
Mapping Data

4 experiments

SNPs within 2kb

348 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928483	protein coding gene	Chr19:8718777-8733433 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024806	protein coding gene	Chr19:6013413-6029389 (+)
A/J	MGP_AJ_G0024774	protein coding gene	Chr19:5693391-5708049 (+)
AKR/J	MGP_AKRJ_G0024749	protein coding gene	Chr19:5781722-5796376 (+)
BALB/cJ	MGP_BALBcJ_G0024774	protein coding gene	Chr19:5796161-5812278 (+)
C3H/HeJ	MGP_C3HHeJ_G0024540	protein coding gene	Chr19:5862533-5877226 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025221	protein coding gene	Chr19:6132929-6147877 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022650	protein coding gene	Chr19:5934669-5951302 (+)
CAST/EiJ	MGP_CASTEiJ_G0024013	protein coding gene	Chr19:5509780-5525228 (+)
CBA/J	MGP_CBAJ_G0024514	protein coding gene	Chr19:6248229-6269144 (+)
DBA/2J	MGP_DBA2J_G0024641	protein coding gene	Chr19:5523629-5538686 (+)
FVB/NJ	MGP_FVBNJ_G0024608	protein coding gene	Chr19:5599274-5613487 (+)
LP/J	MGP_LPJ_G0024728	protein coding gene	Chr19:5901806-5918532 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024635	protein coding gene	Chr19:6118378-6133181 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025270	protein coding gene	Chr19:5826532-5840755 (+)
PWK/PhJ	MGP_PWKPhJ_G0023758	protein coding gene	Chr19:5188938-5203887 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023563	protein coding gene	Chr19:5423532-5440222 (+)
WSB/EiJ	MGP_WSBEiJ_G0024075	protein coding gene	Chr19:5790856-5807799 (+)

Human Ortholog

STX5, syntaxin 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STX5, syntaxin 5
Synonyms

CDG2AA, SED5, STX5A
Links

HGNC:11440

NCBI Gene ID: 6811

neXtProt AC: NX_Q13190

UniProt: Q13190
Chr Location

11q12.3; chr11:62806860-62832051 (-) GRCh38

MGI Vertebrate Homology

Stx5a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: STX5
Gene Tree

Stx5a

Diseases

1 with human STX5 associations

				Human Disease	Mouse Models
				congenital disorder of glycosylation type II IDs congenital disorder of glycosylation type II DOID:0050571 MESH:C535747 OMIM:PS212066

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Gene trapped

5
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

28
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

143
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

96
RefSeq

10
UniProt

10
CCDS

CCDS29542.2

Ensembl

ENSMUSG00000010110 (Evidence)
NCBI Gene

56389

			Length	Strain/Species	Flank
genomic	56389	NCBI Gene Model \| MGI Sequence Detail	14219	C57BL/6J	± kb
transcript	NM_019829	RefSeq \| MGI Sequence Detail	2128	C57BL/6
polypeptide	Q8K1E0	UniProt \| EBI \| MGI Sequence Detail	355	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000015797 syntaxin-5

(term hierarchy)
InterPro Domains

IPR010989 SNARE

IPR045242 Syntaxin

IPR021538 Syntaxin-5, N-terminal, Sly1p-binding domain

IPR006012 Syntaxin/epimorphin, conserved site

IPR000727 Target SNARE coiled-coil homology domain
GlyGen

Q8K1E0 1 site, 1 O-linked glycan (1 site)

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All nucleic 145

cDNA 144

Primer pair 1

Microarray probesets 5

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MGI:1277164, MGI:1917590

Summaries

All 47

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 9
Earliest

J:46012 Hay JC, et al., Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell. 1997 Apr 4;89(1):149-58
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Stx5a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154810	Chr19:8718779-8718825 (+)	14 bp
Tssr154811	Chr19:8718837-8718867 (+)	64 bp
Tssr154812	Chr19:8719158-8719175 (+)	379 bp
Tssr154813	Chr19:8719179-8719229 (+)	416 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24