Ly6g5b MGI Mouse Gene Detail - MGI:2385809 - lymphocyte antigen 6 family member G5B

Symbol

Ly6g5b
Name

lymphocyte antigen 6 family member G5B

Feature Type

protein coding gene
IDs

MGI:2385809
NCBI Gene: 266614
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr17:35332924-35334404 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.59 cM
Mapping Data

1 experiment

Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385809	protein coding gene	Chr17:35332920-35337534 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023618	protein coding gene	Chr17:35255116-35256596 (-)
A/J	MGP_AJ_G0023578	protein coding gene	Chr17:34087612-34089094 (-)
AKR/J	MGP_AKRJ_G0023546	protein coding gene	Chr17:34562454-34563936 (-)
BALB/cJ	MGP_BALBcJ_G0023584	protein coding gene	Chr17:34226277-34227758 (-)
C3H/HeJ	MGP_C3HHeJ_G0023345	protein coding gene	Chr17:34962354-34963836 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024023	protein coding gene	Chr17:36594769-36596249 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021504	protein coding gene	Chr17:31855892-31857374 (-)
CAST/EiJ	MGP_CASTEiJ_G0022841	protein coding gene	Chr17:34959643-34961124 (-)
CBA/J	MGP_CBAJ_G0023323	protein coding gene	Chr17:38098015-38099497 (-)
DBA/2J	MGP_DBA2J_G0023451	protein coding gene	Chr17:33411363-33412844 (-)
FVB/NJ	MGP_FVBNJ_G0023418	protein coding gene	Chr17:33249304-33250784 (-)
LP/J	MGP_LPJ_G0023528	protein coding gene	Chr17:35583084-35584564 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023440	protein coding gene	Chr17:37035982-37037462 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024068	protein coding gene	Chr17:34782600-34784081 (-)
PWK/PhJ	MGP_PWKPhJ_G0022589	protein coding gene	Chr17:32244547-32246031 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022409	protein coding gene	Chr17:32797148-32798631 (-)
WSB/EiJ	MGP_WSBEiJ_G0022905	protein coding gene	Chr17:34902436-34903920 (-)

Human Ortholog

LY6G5B, lymphocyte antigen 6 family member G5B

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LY6G5B, lymphocyte antigen 6 family member G5B
Synonyms

C6orf19, G5b
Links

HGNC:13931

NCBI Gene ID: 58496

neXtProt AC: NX_Q8NDX9

UniProt: Q8NDX9
Chr Location

6p21.33; chr6:31669976-31673776 (+) GRCh38

MGI Vertebrate Homology

Ly6g5b stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LY6G5B
Gene Tree

Ly6g5b

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

2
Targeted

1
Genomic Mutations

1 involving Ly6g5b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

7
cDNA Data

6
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

39
RefSeq

4
UniProt

3
CCDS

CCDS28683.1, CCDS89083.1

Ensembl

ENSMUSG00000043807 (Evidence)
NCBI Gene

266614

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043807	Ensembl Gene Model \| MGI Sequence Detail	1481	C57BL/6J	± kb
transcript	ENSMUST00000062657	Ensembl \| MGI Sequence Detail	1046	Not Applicable
polypeptide	ENSMUSP00000052133	Ensembl \| MGI Sequence Detail	194	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000009990 lymphocyte antigen 6 complex locus protein G5b

(term hierarchy)
InterPro Domains

IPR038773 Lymphocyte antigen 6 complex locus protein G5b
GlyGen

Q8K1T4 2 sites

less

All nucleic 8

cDNA 6

Primer pair 2

Microarray probesets 1

Summaries

All 22

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 4
Earliest

J:78657 Mallya M, et al., Transcriptional Analysis of a Novel Cluster of LY-6 Family Members in the Human and Mouse Major Histocompatibility Complex: Five Genes with Many Splice Forms. Genomics. 2002 Jul;80(1):113-23
Latest

J:340906 Sakurai N, et al., CRISPR/Cas9-mediated disruption of lipocalins, Ly6g5b, and Ly6g5c causes male subfertility in mice. Andrology. 2022 Nov 25;

TSS for Ly6g5b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147750	Chr17:35334645-35334666 (-)	-252 bp
Tssr147749	Chr17:35334505-35334516 (-)	-107 bp
Tssr147748	Chr17:35334447-35334496 (-)	-68 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24