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Gtf3c1 Gene Detail
Summary
  • Symbol
    Gtf3c1
  • Name
    general transcription factor III C 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107887
    NCBI Gene: 233863
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:125240126-125306860 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.01 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1678 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107887
 protein coding gene Chr7:125240126-125306952 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032970
 protein coding gene Chr7:129857460-129927158 (-)
A/J MGP_AJ_G0032953
 protein coding gene Chr7:126453488-126520504 (-)
AKR/J MGP_AKRJ_G0032885
 protein coding gene Chr7:129649707-129716233 (-)
BALB/cJ MGP_BALBcJ_G0032958
 protein coding gene Chr7:126109762-126177066 (-)
C3H/HeJ MGP_C3HHeJ_G0032668
 protein coding gene Chr7:129568201-129640725 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033464
 protein coding gene Chr7:134937885-135006377 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030436
 protein coding gene Chr7:127654490-127720781 (-)
CAST/EiJ MGP_CASTEiJ_G0031996
 protein coding gene Chr7:121327728-121430657 (-)
CBA/J MGP_CBAJ_G0032641
 protein coding gene Chr7:139470451-139543414 (-)
DBA/2J MGP_DBA2J_G0032793
 protein coding gene Chr7:124431284-124498909 (-)
FVB/NJ MGP_FVBNJ_G0032746
 protein coding gene Chr7:124265864-124334159 (-)
LP/J MGP_LPJ_G0032887
 protein coding gene Chr7:131327553-131395593 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032778
 protein coding gene Chr7:140705744-140775892 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033484
 protein coding gene Chr7:128651103-128718394 (-)
PWK/PhJ MGP_PWKPhJ_G0031704
 protein coding gene Chr7:117378071-117478400 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031549
 protein coding gene Chr7:115411624-115538792 (-)
WSB/EiJ MGP_WSBEiJ_G0032109
 protein coding gene Chr7:129617941-129688872 (-)



Homology
more
  • Human Ortholog
    GTF3C1, general transcription factor IIIC subunit 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GTF3C1, general transcription factor IIIC subunit 1
  • Synonyms
    TFIIIC, TFIIIC220, TFIIICalpha
  • Links
    NCBI Gene ID: 2975
    neXtProt AC: NX_Q12789
    UniProt: Q12789

  • Chr Location
    16p12.1; chr16:27459555-27549913 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption may exhibit preimplantation lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    790
  • Tissues
    55
  • cDNA Data
    210
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 233863 NCBI Gene Model | MGI Sequence Detail 66735 C57BL/6J ±  kb
transcript NM_207239 RefSeq | MGI Sequence Detail 6891 ZRU/MplStud  
polypeptide Q8K284 UniProt | EBI | MGI Sequence Detail 2101 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000008325 general transcription factor 3C polypeptide 1
    (term hierarchy)
  • InterPro Domains
    IPR007309 B-block binding subunit of TFIIIC
    IPR035625 Tfc3-like, extended winged-helix domain
    IPR044210 Transcription facto Tfc3-like
  • GlyGen
    Q8K284 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 211
    cDNA 210
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-36464
References
more
  • Summaries
    All 41
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory