About   Help   FAQ
Ints10 Gene Detail
Summary
  • Symbol
    Ints10
  • Name
    integrator complex subunit 10
  • Synonyms
    4921521J11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918135
    NCBI Gene: 70885
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:69245729-69282062 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 33.88 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1103 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918135
 protein coding gene Chr8:69245729-69284319 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033662
 protein coding gene Chr8:68921641-68957011 (+)
A/J MGP_AJ_G0033644
 protein coding gene Chr8:66141244-66176299 (+)
AKR/J MGP_AKRJ_G0033569
 protein coding gene Chr8:67948274-67983343 (+)
BALB/cJ MGP_BALBcJ_G0033640
 protein coding gene Chr8:66355978-66391352 (+)
C3H/HeJ MGP_C3HHeJ_G0033350
 protein coding gene Chr8:68672386-68707424 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034157
 protein coding gene Chr8:71518223-71559594 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031104
 protein coding gene Chr8:61021235-61056468 (+)
CAST/EiJ MGP_CASTEiJ_G0032675
 protein coding gene Chr8:68110704-68149334 (+)
CBA/J MGP_CBAJ_G0033328
 protein coding gene Chr8:74208339-74243328 (+)
DBA/2J MGP_DBA2J_G0033482
 protein coding gene Chr8:65863107-65898294 (+)
FVB/NJ MGP_FVBNJ_G0033423
 protein coding gene Chr8:65015701-65050930 (+)
LP/J MGP_LPJ_G0033570
 protein coding gene Chr8:69020716-69056680 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033467
 protein coding gene Chr8:76867781-76911127 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034175
 protein coding gene Chr8:68223911-68261353 (+)
PWK/PhJ MGP_PWKPhJ_G0032384
 protein coding gene Chr8:65104171-65139726 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032220
 protein coding gene Chr8:67156330-67194345 (+)
WSB/EiJ MGP_WSBEiJ_G0032792
 protein coding gene Chr8:68594599-68629645 (+)



Homology
more
  • Human Ortholog
    INTS10, integrator complex subunit 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INTS10, integrator complex subunit 10
  • Synonyms
    C8orf35, INT10
  • Links
    NCBI Gene ID: 55174
    neXtProt AC: NX_Q9NVR2
    UniProt: Q9NVR2

  • Chr Location
    8p21.3; chr8:19817391-19852083 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    867
  • Tissues
    67
  • cDNA Data
    97
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70885 NCBI Gene Model | MGI Sequence Detail 36334 C57BL/6J ±  kb
    transcript NM_001359129 RefSeq | MGI Sequence Detail 5012 C57BL/6  
    polypeptide Q8K2A7 UniProt | EBI | MGI Sequence Detail 710 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      cDNA 99

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2142559
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory