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Plcl2 Gene Detail
Summary
  • Symbol
    Plcl2
  • Name
    phospholipase C-like 2
  • Synonyms
    mKIAA1092, Plce2, PRIP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352756
    NCBI Gene: 224860
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:50816431-50995512 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 25.86 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5691 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352756
 protein coding gene Chr17:50815893-50995522 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023882
 protein coding gene Chr17:51932285-52126984 (+)
A/J MGP_AJ_G0023842
 protein coding gene Chr17:50537555-50712555 (+)
AKR/J MGP_AKRJ_G0023810
 protein coding gene Chr17:51088161-51270526 (+)
BALB/cJ MGP_BALBcJ_G0023844
 protein coding gene Chr17:50432884-50613759 (+)
C3H/HeJ MGP_C3HHeJ_G0023607
 protein coding gene Chr17:51786721-51966338 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024287
 protein coding gene Chr17:54018763-54201640 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021736
 protein coding gene Chr17:47255902-47421287 (+)
CAST/EiJ MGP_CASTEiJ_G0023089
 protein coding gene Chr17:52022225-52210387 (+)
CBA/J MGP_CBAJ_G0023583
 protein coding gene Chr17:56033228-56224396 (+)
DBA/2J MGP_DBA2J_G0023712
 protein coding gene Chr17:49292533-49467803 (+)
FVB/NJ MGP_FVBNJ_G0023678
 protein coding gene Chr17:48970481-49145013 (+)
LP/J MGP_LPJ_G0023792
 protein coding gene Chr17:52651777-52830515 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023706
 protein coding gene Chr17:55399813-55586562 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024333
 protein coding gene Chr17:51395996-51580693 (+)
PWK/PhJ MGP_PWKPhJ_G0022834
 protein coding gene Chr17:48739714-48922178 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022648
 protein coding gene Chr17:48362226-48539193 (+)
WSB/EiJ MGP_WSBEiJ_G0023153
 protein coding gene Chr17:52010337-52194961 (+)



Homology
more
  • Human Ortholog
    PLCL2, phospholipase C like 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLCL2, phospholipase C like 2
  • Synonyms
    PLCE2
  • Links
    NCBI Gene ID: 23228
    neXtProt AC: NX_Q9UPR0
    UniProt: Q9UPR0

  • Chr Location
    3p24.3; chr3:16802651-17090606 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this gene is compatible with normal immune cell development, though the B cell response is dysregulated.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    95
  • cDNA Data
    46
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038910 Ensembl Gene Model | MGI Sequence Detail 179082 C57BL/6J ±  kb
    transcript ENSMUST00000043938 Ensembl | MGI Sequence Detail 4185 Not Applicable  
    polypeptide ENSMUSP00000046584 Ensembl | MGI Sequence Detail 1128 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000012841 inactive phospholipase C-like protein 2
      (term hierarchy)
    • InterPro Domains
      IPR000008 C2 domain
      IPR035892 C2 domain superfamily
      IPR011992 EF-hand domain pair
      IPR028382 Inactive phospholipase C-like protein 2, EF-hand domain
      IPR011993 PH-like domain superfamily
      IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
      IPR001192 Phosphoinositide phospholipase C family
      IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
      IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
      IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
      IPR001849 Pleckstrin homology domain
    • GlyGen
      Q8K394 3 sites, 4 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 46
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:58930 Otsuki M, et al., Identification and characterization of a new phospholipase C-like protein, PLC-L(2). Biochem Biophys Res Commun. 1999 Dec 9;266(1):97-103
    • Latest
      J:327722 Gao J, et al., Phospholipase C-related but catalytically inactive protein acts as a positive regulator of insulin signalling in adipocytes. J Cell Sci. 2022 Jan 1;135(1):jcs258584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory