Padi6 MGI Mouse Gene Detail - MGI:2655198 - peptidyl arginine deiminase, type VI

Symbol

Padi6
Name

peptidyl arginine deiminase, type VI
Synonyms

ePAD, Pad6, Padi5

Feature Type

protein coding gene
IDs

MGI:2655198
NCBI Gene: 242726
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:140454666-140469954 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 72.26 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

185 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2655198	protein coding gene	Chr4:140454666-140469954 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029028	protein coding gene	Chr4:143692727-143712493 (-)
A/J	MGP_AJ_G0028987	protein coding gene	Chr4:137474938-137490117 (-)
AKR/J	MGP_AKRJ_G0028939	protein coding gene	Chr4:141448490-141463216 (-)
BALB/cJ	MGP_BALBcJ_G0029011	protein coding gene	Chr4:138169695-138184867 (-)
C3H/HeJ	MGP_C3HHeJ_G0028725	protein coding gene	Chr4:141831321-141846564 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029452	protein coding gene	Chr4:148745824-148762193 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026723	protein coding gene	Chr4:130410979-130426135 (-)
CAST/EiJ	MGP_CASTEiJ_G0028157	protein coding gene	Chr4:140067300-140083778 (-)
CBA/J	MGP_CBAJ_G0028689	protein coding gene	Chr4:152989725-153005120 (-)
DBA/2J	MGP_DBA2J_G0028839	protein coding gene	Chr4:137876896-137892003 (-)
FVB/NJ	MGP_FVBNJ_G0028806	protein coding gene	Chr4:136969940-136985151 (-)
LP/J	MGP_LPJ_G0028938	protein coding gene	Chr4:143733476-143749625 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028832	protein coding gene	Chr4:156912519-156929411 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029490	protein coding gene	Chr4:141973519-141989659 (-)
PWK/PhJ	MGP_PWKPhJ_G0027878	protein coding gene	Chr4:134751383-134766704 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027703	protein coding gene	Chr4:137790754-137811273 (-)
WSB/EiJ	MGP_WSBEiJ_G0028235	protein coding gene	Chr4:142256081-142274199 (-)

Human Ortholog

PADI6, peptidyl arginine deiminase 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PADI6, peptidyl arginine deiminase 6
Synonyms

hPADVI, OZEMA16, PREMBL2
Links

HGNC:20449

NCBI Gene ID: 353238

neXtProt AC: NX_Q6TGC4

UniProt: Q6TGC4
Chr Location

1p36.13; chr1:17372196-17401699 (+) GRCh38

MGI Vertebrate Homology

Padi6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PADI6
Protein SuperFamily

Protein-arginine_deiminase
Gene Tree

Padi6

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Phenotype Summary

5 phenotypes from 2 alleles in 3 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

3
Targeted

7
Genomic Mutations

3 involving Padi6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit altered oocyte cytoplasmic structures that lead to a failure of zygotes to progress beyond the 2 cell stage and female infertility.

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All GO Annotations

16
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

882
Tissues

138
cDNA Data

46
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS38936.1

Ensembl

ENSMUSG00000040935 (Evidence)
NCBI Gene

242726

			Length	Strain/Species	Flank
genomic	242726	NCBI Gene Model \| MGI Sequence Detail	15289	C57BL/6J	± kb
transcript	NM_153106	RefSeq \| MGI Sequence Detail	2333	ZRU/MplStud
polypeptide	Q8K3V4	UniProt \| EBI \| MGI Sequence Detail	682	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012223 protein-arginine deiminase type-6

(term hierarchy)
EC

3.5.3.15
InterPro Domains

IPR008972 Cupredoxin

IPR038685 PAD, N-terminal domain superfamily

IPR004303 Protein-arginine deiminase

IPR036556 Protein-arginine deiminase, central domain superfamily

IPR013530 Protein-arginine deiminase, C-terminal

IPR013733 Protein-arginine deiminase (PAD), central domain

IPR013732 Protein-arginine deiminase (PAD), N-terminal

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All nucleic 49

cDNA 46

Primer pair 2

Other 1

Microarray probesets 3

Summaries

All 53

Developmental Gene Expression 16

Gene Ontology 10

Phenotypes 16
Earliest

J:82688 Wright PW, et al., ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets. Dev Biol. 2003 Apr 1;256(1):73-88
Latest

J:346894 Giaccari C, et al., A maternal-effect Padi6 variant causes nuclear and cytoplasmic abnormalities in oocytes, as well as failure of epigenetic reprogramming and zygotic genome activation in embryos. Genes Dev. 2024 Mar 22;38(3-4):131-150

TSS for Padi6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr44276	Chr4:140469950-140469955 (-)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24