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Polb Gene Detail
Summary
  • Symbol
    Polb
  • Name
    polymerase (DNA directed), beta
  • Synonyms
    A430088C08Rik, Pol beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:97740
    NCBI Gene: 18970
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:23118142-23143451 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.42 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    812 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97740
 protein coding gene Chr8:23118135-23143482 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033456
 protein coding gene Chr8:20484143-20513623 (-)
A/J MGP_AJ_G0033436
 protein coding gene Chr8:19819802-19845531 (-)
AKR/J MGP_AKRJ_G0033361
 protein coding gene Chr8:20469706-20497829 (-)
BALB/cJ MGP_BALBcJ_G0033432
 protein coding gene Chr8:19943388-19969633 (-)
C3H/HeJ MGP_C3HHeJ_G0033146
 protein coding gene Chr8:20670983-20697429 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033948
 protein coding gene Chr8:21353975-21381534 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030901
 protein coding gene Chr8:17148244-17175622 (-)
CAST/EiJ MGP_CASTEiJ_G0032472
 protein coding gene Chr8:20085088-20111947 (-)
CBA/J MGP_CBAJ_G0033121
 protein coding gene Chr8:22206631-22237436 (-)
DBA/2J MGP_DBA2J_G0033276
 protein coding gene Chr8:19785206-19810604 (-)
FVB/NJ MGP_FVBNJ_G0033220
 protein coding gene Chr8:19585798-19610733 (-)
LP/J MGP_LPJ_G0033365
 protein coding gene Chr8:20481772-20507508 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033263
 protein coding gene Chr8:21802551-21831209 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033967
 protein coding gene Chr8:20376909-20405109 (-)
PWK/PhJ MGP_PWKPhJ_G0032184
 protein coding gene Chr8:19372564-19398215 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032017
 protein coding gene Chr8:19755700-19781580 (-)
WSB/EiJ MGP_WSBEiJ_G0032588
 protein coding gene Chr8:20579004-20607881 (-)



Homology
more
  • Human Ortholog
    POLB, DNA polymerase beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLB, DNA polymerase beta
  • Links
    NCBI Gene ID: 5423
    neXtProt AC: NX_P06746
    UniProt: P06746

  • Chr Location
    8p11.21; chr8:42338454-42371808 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Polb mouse models; 1 with human POLB associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    86 phenotypes from 5 alleles in 5 genetic backgrounds
    2 images
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for one knock-out allele die from E10.5 to birth and those for another one exhibit embryonic growth retardation, abnormal neurogenesis, and neonatal lethality due to respiratory failure. Hypomorphic allele mice develop systemic lupus erythematosus-like phentoypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    26
  • cDNA Data
    10
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031536 Ensembl Gene Model | MGI Sequence Detail 25310 C57BL/6J ±  kb
    transcript ENSMUST00000033938 Ensembl | MGI Sequence Detail 1201 Not Applicable  
    polypeptide ENSMUSP00000033938 Ensembl | MGI Sequence Detail 335 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 13
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13578, MGI:2444980
    References
    more
    • Summaries
      All 116
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 16
      Phenotypes 48
    • Earliest
      J:14794 Yamaguchi M, et al., Murine DNA polymerase beta gene: mapping of transcription initiation sites and the nucleotide sequence of the putative promoter region. Mol Cell Biol. 1987 May;7(5):2012-8
    • Latest
      J:353954 Marmolejo-Garza A, et al., Nicotinamide riboside modulates the reactive species interactome, bioenergetic status and proteomic landscape in a brain-region-specific manner. Neurobiol Dis. 2024 Oct 1;200:106645
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory