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Spag16 Gene Detail
Summary
  • Symbol
    Spag16
  • Name
    sperm associated antigen 16
  • Synonyms
    4921511D23Rik, 4930524F24Rik, 4930585K05Rik, Pf20, Wdr29
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913972
    NCBI Gene: 66722
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:69866129-70764291 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 35.04 cM, cytoband C3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    25871 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913972
protein coding gene Chr1:69866031-70764291 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016122
protein coding gene Chr1:70208647-71128235 (+)
A/J MGP_AJ_G0016105
protein coding gene Chr1:67719210-68610546 (+)
AKR/J MGP_AKRJ_G0016062
protein coding gene Chr1:69666062-70596369 (+)
BALB/cJ MGP_BALBcJ_G0016060
protein coding gene Chr1:67823715-68729475 (+)
C3H/HeJ MGP_C3HHeJ_G0015891
protein coding gene Chr1:69990563-70918988 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016513
protein coding gene Chr1:72886704-73858830 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014234
protein coding gene Chr1:63472678-64344631 (+)
CAST/EiJ MGP_CASTEiJ_G0015475
protein coding gene Chr1:69212220-70159136 (+)
CBA/J MGP_CBAJ_G0015864
protein coding gene Chr1:75329852-76327005 (+)
DBA/2J MGP_DBA2J_G0015965
protein coding gene Chr1:67109780-68016445 (+)
FVB/NJ MGP_FVBNJ_G0015968
protein coding gene Chr1:66301066-67195680 (+)
LP/J MGP_LPJ_G0016037
protein coding gene Chr1:71260446-72186381 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015988
protein coding gene Chr1:78709370-79837894 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016560
protein coding gene Chr1:69638256-70570795 (+)
PWK/PhJ MGP_PWKPhJ_G0015262
protein coding gene Chr1:66512117-67418564 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015041
protein coding gene Chr1:69027784-69980517 (+)
WSB/EiJ MGP_WSBEiJ_G0015537
protein coding gene Chr1:69442709-70383709 (+)



Homology
more
  • Human Ortholog
    SPAG16, sperm associated antigen 16
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPAG16, sperm associated antigen 16
  • Synonyms
    PF20, WDR29
  • Links
    NCBI Gene ID: 79582
    neXtProt AC: NX_Q8N0X2
    UniProt: Q8N0X2

  • Chr Location
    2q34; chr2:213284389-214410501 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Chimeric males carrying one copy of the mutated allele have impaired spermatogenesis, a significant loss of germ cells at the round spermatid stage, and disorganized sperm axoneme structure. No offspring carrying the mutated allele are produced from matings using male chimeras.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053153 Ensembl Gene Model | MGI Sequence Detail 898163 C57BL/6J ±  kb
    transcript ENSMUST00000065425 Ensembl | MGI Sequence Detail 2126 Not Applicable  
    polypeptide ENSMUSP00000069821 Ensembl | MGI Sequence Detail 639 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922324, MGI:1923198, MGI:2138527
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 1
      Gene Ontology 12
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:307547 Miyata H, et al., Analysis of the sperm flagellar axoneme using gene-modified mice. Exp Anim. 2020 Nov 12;69(4):374-381

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/05/2024
    MGI 6.24
    The Jackson Laboratory