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Svil Gene Detail
Summary
  • Symbol
    Svil
  • Name
    supervillin
  • Synonyms
    B430302E16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147319
    NCBI Gene: 225115
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:4920540-5119299 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 3.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5304 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147319
 protein coding gene Chr18:4920497-5119299 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024125
 protein coding gene Chr18:1762007-1975657 (+)
A/J MGP_AJ_G0024087
 protein coding gene Chr18:1799889-1998948 (+)
AKR/J MGP_AKRJ_G0024055
 protein coding gene Chr18:1801979-2006976 (+)
BALB/cJ MGP_BALBcJ_G0024087
 protein coding gene Chr18:1780925-1986360 (+)
C3H/HeJ MGP_C3HHeJ_G0023852
 protein coding gene Chr18:1766137-1970977 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024532
 protein coding gene Chr18:1914487-2125645 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021971
 protein coding gene Chr18:1590520-1790327 (+)
CAST/EiJ MGP_CASTEiJ_G0023331
 protein coding gene Chr18:1735704-1944702 (+)
CBA/J MGP_CBAJ_G0023826
 protein coding gene Chr18:1884995-2107125 (+)
DBA/2J MGP_DBA2J_G0023954
 protein coding gene Chr18:1721134-1931771 (+)
FVB/NJ MGP_FVBNJ_G0023920
 protein coding gene Chr18:1694938-1899535 (+)
LP/J MGP_LPJ_G0024038
 protein coding gene Chr18:1859389-2068811 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023948
 protein coding gene Chr18:1911675-2118792 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024577
 protein coding gene Chr18:1732818-1942190 (+)
PWK/PhJ MGP_PWKPhJ_G0023076
 protein coding gene Chr18:1708556-1910153 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022887
 protein coding gene Chr18:2006702-2239229 (+)
WSB/EiJ MGP_WSBEiJ_G0023397
 protein coding gene Chr18:1761636-1969243 (+)



Homology
more
  • Human Ortholog
    SVIL, supervillin
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SVIL, supervillin
  • Synonyms
    MFM10
  • Links
    NCBI Gene ID: 6840
    neXtProt AC: NX_O95425
    UniProt: O95425

  • Chr Location
    10p11.23; chr10:29457338-29736959 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SVIL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit enhanched adhesion and thrombus formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    879
  • Tissues
    19
  • cDNA Data
    104
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024236 Ensembl Gene Model | MGI Sequence Detail 198760 C57BL/6J ±  kb
transcript ENSMUST00000210707 Ensembl | MGI Sequence Detail 7633 Not Applicable  
polypeptide ENSMUSP00000147843 Ensembl | MGI Sequence Detail 2257 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 106
    cDNA 105
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:1925796
References
more
  • Summaries
    All 49
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory