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Mepe Gene Detail
Summary
  • Symbol
    Mepe
  • Name
    matrix extracellular phosphoglycoprotein with ASARM motif (bone)
  • Synonyms
    OF45
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137384
    NCBI Gene: 94111
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:104473195-104486477 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 50.68 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    818 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137384
protein coding gene Chr5:104473195-104486477 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029813
protein coding gene Chr5:106000131-106015746 (+)
A/J MGP_AJ_G0029777
protein coding gene Chr5:102010258-102021997 (+)
AKR/J MGP_AKRJ_G0029724
protein coding gene Chr5:105277091-105333137 (+)
BALB/cJ MGP_BALBcJ_G0029789
protein coding gene Chr5:103075835-103087512 (+)
C3H/HeJ MGP_C3HHeJ_G0029511
protein coding gene Chr5:105701874-105719330 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030244
protein coding gene Chr5:110331055-110342612 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027479
protein coding gene Chr5:97137768-97148826 (+)
CAST/EiJ MGP_CASTEiJ_G0028923
protein coding gene Chr5:104425071-104438542 (+)
CBA/J MGP_CBAJ_G0029482
protein coding gene Chr5:114159513-114180687 (+)
DBA/2J MGP_DBA2J_G0029626
protein coding gene Chr5:102199856-102214668 (+)
FVB/NJ MGP_FVBNJ_G0029585
protein coding gene Chr5:100988303-101000621 (+)
LP/J MGP_LPJ_G0029714
protein coding gene Chr5:106581075-106598078 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029614
protein coding gene Chr5:119105544-119121870 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030277
protein coding gene Chr5:104833908-104847603 (+)
PWK/PhJ MGP_PWKPhJ_G0028640
protein coding gene Chr5:100653455-100665385 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028476
protein coding gene Chr5:102484270-102495971 (+)
WSB/EiJ MGP_WSBEiJ_G0029001
protein coding gene Chr5:105214919-105227206 (+)



Homology
more
  • Human Ortholog
    MEPE, matrix extracellular phosphoglycoprotein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEPE, matrix extracellular phosphoglycoprotein
  • Synonyms
    OF45
  • Links
    NCBI Gene ID: 56955
    neXtProt AC: NX_Q9NQ76
    UniProt: Q9NQ76

  • Chr Location
    4q22.1; chr4:87821398-87846814 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have increased amounts of trabecular bone in their skeleton and undergo less age related bone loss. Otherwise, they display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 94111 NCBI Gene Model | MGI Sequence Detail 13283 C57BL/6J ±  kb
    transcript NM_053172 RefSeq | MGI Sequence Detail 1682 Not Specified  
    polypeptide Q8K4L6 UniProt | EBI | MGI Sequence Detail 441 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 6
      Primer pair 4
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory