Onecut3 MGI Mouse Gene Detail - MGI:1891409 - one cut domain, family member 3

Symbol

Onecut3
Name

one cut domain, family member 3
Synonyms

Oc3, OC-3

Feature Type

protein coding gene
IDs

MGI:1891409
NCBI Gene: 246086
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr10:80330740-80353100 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

1 experiment

SNPs within 2kb

546 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891409	protein coding gene	Chr10:80330669-80353110 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017504	protein coding gene	Chr10:81108195-81135139 (+)
A/J	MGP_AJ_G0017482	protein coding gene	Chr10:78265127-78290464 (+)
AKR/J	MGP_AKRJ_G0017443	protein coding gene	Chr10:80418516-80440579 (+)
BALB/cJ	MGP_BALBcJ_G0017444	protein coding gene	Chr10:78495207-78518683 (+)
C3H/HeJ	MGP_C3HHeJ_G0017267	protein coding gene	Chr10:80501488-80526315 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017898	protein coding gene	Chr10:83907722-83938419 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015586	protein coding gene	Chr10:74492457-74513984 (+)
CAST/EiJ	MGP_CASTEiJ_G0016834	protein coding gene	Chr10:80724643-80748868 (+)
CBA/J	MGP_CBAJ_G0017239	protein coding gene	Chr10:87155328-87189671 (+)
DBA/2J	MGP_DBA2J_G0017345	protein coding gene	Chr10:77481166-77503352 (+)
FVB/NJ	MGP_FVBNJ_G0017339	protein coding gene	Chr10:76688470-76711993 (+)
LP/J	MGP_LPJ_G0017416	protein coding gene	Chr10:81585374-81611773 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017365	protein coding gene	Chr10:89107760-89134827 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017939	protein coding gene	Chr10:80396817-80424381 (+)
PWK/PhJ	MGP_PWKPhJ_G0016615	protein coding gene	Chr10:77361554-77385634 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016404	protein coding gene	Chr10:79362550-79390398 (+)
WSB/EiJ	MGP_WSBEiJ_G0016894	protein coding gene	Chr10:80435978-80463834 (+)

Human Ortholog

ONECUT3, one cut homeobox 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ONECUT3, one cut homeobox 3
Synonyms

OC3
Links

HGNC:13399

NCBI Gene ID: 390874

neXtProt AC: NX_O60422

UniProt: O60422
Chr Location

19p13.3

MGI Vertebrate Homology

Onecut3 stringent orthology
1 human;1 mouse;2 zebrafish
HCOP

vertebrate homology predictions: ONECUT3
Gene Tree

Onecut3

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
4 phenotypes from multigenic genotypes
7 phenotype references

All Mutations and Alleles

2
Chemically induced (other)

1
Targeted

1
Genomic Mutations

1 involving Onecut3
Find Mice (IMSR)

14 strains or lines available

Mice homozygous for a reporter/null allele display normal pancreas and gut development with no apparent alterations in enteroendocrine differentiation.

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

986
Tissues

157
cDNA Data

4
Literature Summary

22

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase onecut3

ZFIN onecut3a

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All Sequences

27
RefSeq

2
UniProt

1
CCDS

CCDS24023.1

Ensembl

ENSMUSG00000045518 (Evidence)
NCBI Gene

246086

			Length	Strain/Species	Flank
genomic	246086	NCBI Gene Model \| MGI Sequence Detail	22361	C57BL/6J	± kb
transcript	NM_139226	RefSeq \| MGI Sequence Detail	4705	C57BL/6
polypeptide	Q8K557	UniProt \| EBI \| MGI Sequence Detail	490	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011641 one cut domain family member 3

(term hierarchy)
InterPro Domains

IPR003350 CUT domain

IPR051649 CUT Homeobox Domain-Containing Protein

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

IPR010982 Lambda repressor-like, DNA-binding domain superfamily

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All nucleic 7

cDNA 4

Primer pair 3

Microarray probesets 2

Summaries

All 43

Developmental Gene Expression 22

Gene Ontology 4

Phenotypes 7
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:353339 Butts JC, et al., A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. Dev Cell. 2024 Aug 19;59(16):2171-2188.e7

TSS for Onecut3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94572	Chr10:80330689-80330707 (+)	-42 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24