Crb3 MGI Mouse Gene Detail - MGI:2670904

Symbol

Crb3
Name

crumbs family member 3

Feature Type

protein coding gene
IDs

MGI:2670904
NCBI Gene: 224912
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr17:57368583-57372920 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 29.65 cM
Mapping Data

2 experiments

SNPs within 2kb

158 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2670904	protein coding gene	Chr17:57366105-57372920 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023952	protein coding gene	Chr17:58810377-58821631 (+)
A/J	MGP_AJ_G0023910	protein coding gene	Chr17:57185097-57192450 (+)
AKR/J	MGP_AKRJ_G0023879	protein coding gene	Chr17:57906502-57913294 (+)
BALB/cJ	MGP_BALBcJ_G0023911	protein coding gene	Chr17:57023046-57030446 (+)
C3H/HeJ	MGP_C3HHeJ_G0023675	protein coding gene	Chr17:58627241-58635928 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024357	protein coding gene	Chr17:61091775-61098586 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021803	protein coding gene	Chr17:53662152-53668981 (+)
CAST/EiJ	MGP_CASTEiJ_G0023157	protein coding gene	Chr17:58924233-58933765 (+)
CBA/J	MGP_CBAJ_G0023651	protein coding gene	Chr17:63471799-63488115 (+)
DBA/2J	MGP_DBA2J_G0023779	protein coding gene	Chr17:55879504-55886967 (+)
FVB/NJ	MGP_FVBNJ_G0023745	protein coding gene	Chr17:55452320-55459135 (+)
LP/J	MGP_LPJ_G0023861	protein coding gene	Chr17:59489805-59515451 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023773	protein coding gene	Chr17:62929349-62937072 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024401	protein coding gene	Chr17:58268017-58274792 (+)
PWK/PhJ	MGP_PWKPhJ_G0022903	protein coding gene	Chr17:55248306-55255780 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022714	protein coding gene	Chr17:55038017-55046586 (+)
WSB/EiJ	MGP_WSBEiJ_G0023223	protein coding gene	Chr17:58892321-58900120 (+)

Human Ortholog

CRB3, crumbs cell polarity complex component 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRB3, crumbs cell polarity complex component 3
Links

HGNC:20237

NCBI Gene ID: 92359

neXtProt AC: NX_Q9BUF7

UniProt: Q9BUF7
Chr Location

19p13.3; chr19:6463777-6467221 (+) GRCh38

MGI Vertebrate Homology

Crb3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CRB3
Gene Tree

Crb3

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Phenotype Summary

26 phenotypes from 4 alleles in 4 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

1
Gene trapped

1
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit neonatal lethality likely due to respiratory distress, abnormal pulmonary alveolus morphology, kidney cysts and abnormal small intestinal morphology.

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All GO Annotations

14
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

789
Tissues

51
cDNA Data

11
Literature Summary

37

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase crb3

ZFIN crb3a, crb3b

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All Sequences

57
RefSeq

14
UniProt

2
CCDS

CCDS28924.1, CCDS84327.1

Ensembl

ENSMUSG00000044279 (Evidence)
NCBI Gene

224912

			Length	Strain/Species	Flank
genomic	224912	NCBI Gene Model \| MGI Sequence Detail	4338	C57BL/6J	± kb
transcript	NM_001431885	RefSeq \| MGI Sequence Detail	1390	C57BL/6
polypeptide	Q8QZT4	UniProt \| EBI \| MGI Sequence Detail	113	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005850 protein crumbs homolog 3

(term hierarchy)
GlyGen

Q8QZT4 1 site

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 5

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MGI:2146967, MGI:2146999

Summaries

All 73

Developmental Gene Expression 37

Gene Ontology 8

Phenotypes 10
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:336187 Barlow HR, et al., Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass. Dev Biol. 2023 Jul;499:59-74

TSS for Crb3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145365	Chr17:57367735-57367757 (+)	-837 bp
Tssr145366	Chr17:57369260-57369315 (+)	705 bp
Tssr145367	Chr17:57369317-57369337 (+)	744 bp
Tssr145368	Chr17:57369353-57369360 (+)	774 bp
Tssr145369	Chr17:57369486-57369523 (+)	922 bp
Tssr145370	Chr17:57369525-57369542 (+)	951 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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