Fam161a MGI Mouse Gene Detail - MGI:1921123 - family with sequence similarity 161, member A

Symbol

Fam161a
Name

family with sequence similarity 161, member A
Synonyms

4930430E16Rik

Feature Type

protein coding gene
IDs

MGI:1921123
NCBI Gene: 73873
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:22957531-22980788 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 14.25 cM, cytoband A3.3
Mapping Data

2 experiments

SNPs within 2kb

705 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921123	protein coding gene	Chr11:22956725-22995743 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018084	protein coding gene	Chr11:20722237-20746011 (+)
A/J	MGP_AJ_G0018057	protein coding gene	Chr11:19932634-19956698 (+)
AKR/J	MGP_AKRJ_G0018021	protein coding gene	Chr11:20646243-20669366 (+)
BALB/cJ	MGP_BALBcJ_G0018025	protein coding gene	Chr11:20068040-20092047 (+)
C3H/HeJ	MGP_C3HHeJ_G0017839	protein coding gene	Chr11:20521349-20547004 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018477	protein coding gene	Chr11:21577060-21600882 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016135	protein coding gene	Chr11:18834336-18858020 (+)
CAST/EiJ	MGP_CASTEiJ_G0017400	protein coding gene	Chr11:20575995-20601798 (+)
CBA/J	MGP_CBAJ_G0017813	protein coding gene	Chr11:22533257-22556832 (+)
DBA/2J	MGP_DBA2J_G0017923	protein coding gene	Chr11:19863013-19885880 (+)
FVB/NJ	MGP_FVBNJ_G0017915	protein coding gene	Chr11:19639480-19662247 (+)
LP/J	MGP_LPJ_G0017994	protein coding gene	Chr11:20837160-20860250 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017941	protein coding gene	Chr11:23006198-23030572 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018518	protein coding gene	Chr11:20754205-20779584 (+)
PWK/PhJ	MGP_PWKPhJ_G0017181	protein coding gene	Chr11:19897561-19922494 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016978	protein coding gene	Chr11:20495153-20524549 (+)
WSB/EiJ	MGP_WSBEiJ_G0017454	protein coding gene	Chr11:20379276-20402921 (+)

Human Ortholog

FAM161A, FAM161 centrosomal protein A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM161A, FAM161 centrosomal protein A
Synonyms

RP28
Links

HGNC:25808

NCBI Gene ID: 84140

neXtProt AC: NX_Q3B820

UniProt: Q3B820
Chr Location

2p15; chr2:61800240-61854143 (-) GRCh38

MGI Vertebrate Homology

Fam161a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAM161A
Gene Tree

Fam161a

Diseases

1 with Fam161a mouse models; 1 with human FAM161A associations

Human Disease

Mouse Models

retinitis pigmentosa 28

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

32 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Fam161a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele show early loss of visual function associated with alterations in photoreceptor ciliary structure, abnormal photoreceptor outer segment morphology, microgliosis, and progressive retinal photoreceptor degeneration.

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All GO Annotations

27
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

779
Tissues

23
cDNA Data

23
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fam161a

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All Sequences

155
RefSeq

102
UniProt

9
CCDS

CCDS48757.1

Ensembl

ENSMUSG00000049811 (Evidence)
NCBI Gene

73873

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049811	Ensembl Gene Model \| MGI Sequence Detail	23258	C57BL/6J	± kb
transcript	ENSMUST00000208732	Ensembl \| MGI Sequence Detail	2034	Not Applicable
polypeptide	ENSMUSP00000146368	Ensembl \| MGI Sequence Detail	562	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000030937 protein FAM161A

(term hierarchy)
InterPro Domains

IPR051655 FAM161

IPR019579 Protein FAM161A/B

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All nucleic 24

cDNA 24

Microarray probesets 4

Summaries

All 48

Developmental Gene Expression 4

Diseases 1

Gene Ontology 8

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fam161a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100597	Chr11:22957523-22957536 (+)	-1 bp
Tssr100598	Chr11:22958337-22958391 (+)	833 bp
Tssr100599	Chr11:22958420-22958500 (+)	929 bp
Tssr100600	Chr11:22958521-22958532 (+)	996 bp
Tssr100601	Chr11:22958542-22958553 (+)	1,017 bp
Tssr100602	Chr11:22960976-22961001 (+)	3,458 bp
Tssr3445	Chr11:22970281-22970288 (+)	12,754 bp
Tssr100603	Chr11:22970346-22970355 (+)	12,820 bp
Tssr100604	Chr11:22970464-22970486 (+)	12,944 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24