Nectin4 MGI Mouse Gene Detail - MGI:1918990 - nectin cell adhesion molecule 4

Symbol

Nectin4
Name

nectin cell adhesion molecule 4
Synonyms

1200017F15Rik, nectin 4, Prr4, Pvrl4

Feature Type

protein coding gene
IDs

MGI:1918990
NCBI Gene: 71740
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:171197741-171215855 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.37 cM, cytoband H2
Mapping Data

2 experiments

SNPs within 2kb

469 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918990	protein coding gene	Chr1:171197667-171216166 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016759	protein coding gene	Chr1:177167373-177189254 (+)
A/J	MGP_AJ_G0016739	protein coding gene	Chr1:169946406-169964825 (+)
AKR/J	MGP_AKRJ_G0016705	protein coding gene	Chr1:175041412-175059785 (+)
BALB/cJ	MGP_BALBcJ_G0016700	protein coding gene	Chr1:170440941-170459730 (+)
C3H/HeJ	MGP_C3HHeJ_G0016523	protein coding gene	Chr1:175286167-175314387 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017161	protein coding gene	Chr1:183058166-183079424 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014869	protein coding gene	Chr1:161635540-161653587 (+)
CAST/EiJ	MGP_CASTEiJ_G0016104	protein coding gene	Chr1:174916715-174936621 (+)
CBA/J	MGP_CBAJ_G0016498	protein coding gene	Chr1:189566365-189586949 (+)
DBA/2J	MGP_DBA2J_G0016605	protein coding gene	Chr1:168788949-168807520 (+)
FVB/NJ	MGP_FVBNJ_G0016601	protein coding gene	Chr1:167138781-167159063 (+)
LP/J	MGP_LPJ_G0016676	protein coding gene	Chr1:178280027-178300527 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016628	protein coding gene	Chr1:196846026-196865283 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017198	protein coding gene	Chr1:174910972-174929356 (+)
PWK/PhJ	MGP_PWKPhJ_G0015890	protein coding gene	Chr1:168012097-168030576 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015674	protein coding gene	Chr1:173698845-173720408 (+)
WSB/EiJ	MGP_WSBEiJ_G0016166	protein coding gene	Chr1:175028020-175047683 (+)

Human Ortholog

NECTIN4, nectin cell adhesion molecule 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NECTIN4, nectin cell adhesion molecule 4
Synonyms

EDSS1, LNIR, nectin-4, PRR4, PVRL4
Links

HGNC:19688

NCBI Gene ID: 81607

neXtProt AC: NX_Q96NY8

UniProt: Q96NY8
Chr Location

1q23.3; chr1:161070998-161089558 (-) GRCh38

MGI Vertebrate Homology

Nectin4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NECTIN4
Gene Tree

Nectin4

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Endonuclease-mediated

6
Gene trapped

2
Targeted

1
Genomic Mutations

2 involving Nectin4
Incidental Mutations

APF
Find Mice (IMSR)

36 strains or lines available

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

849
Tissues

56
cDNA Data

24
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nectin4

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All Sequences

39
RefSeq

4
UniProt

1
CCDS

CCDS15493.1, CCDS48442.1

Ensembl

ENSMUSG00000006411 (Evidence)
NCBI Gene

71740

			Length	Strain/Species	Flank
genomic	71740	NCBI Gene Model \| MGI Sequence Detail	18115	C57BL/6J	± kb
transcript	NM_027893	RefSeq \| MGI Sequence Detail	3509	C57BL/6
polypeptide	Q8R007	UniProt \| EBI \| MGI Sequence Detail	508	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013503 nectin-4

(term hierarchy)
InterPro Domains

IPR013162 CD80-like, immunoglobulin C2-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain

IPR033320 Nectin-3/4, second Ig domain

IPR051427 Nectin and Nectin-like
GlyGen

Q8R007 1 site

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All nucleic 30

cDNA 25

Primer pair 3

Other 2

Microarray probesets 4

Summaries

All 48

Developmental Gene Expression 10

Gene Ontology 6

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nectin4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10024	Chr1:171197620-171197659 (+)	-101 bp
Tssr10025	Chr1:171197660-171197679 (+)	-71 bp
Tssr10026	Chr1:171197681-171197698 (+)	-51 bp
Tssr10027	Chr1:171197728-171197739 (+)	-7 bp
Tssr10028	Chr1:171197913-171197927 (+)	179 bp
Tssr10029	Chr1:171197953-171197976 (+)	224 bp
Tssr10030	Chr1:171207712-171207734 (+)	9,982 bp
Tssr10031	Chr1:171211082-171211088 (+)	13,344 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24