Suox MGI Mouse Gene Detail - MGI:2446117

Symbol

Suox
Name

sulfite oxidase
Synonyms

MGC:28458, SO

Feature Type

protein coding gene
IDs

MGI:2446117
NCBI Gene: 211389
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:128505756-128509787 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 77.12 cM
Mapping Data

1 experiment

SNPs within 2kb

142 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446117	protein coding gene	Chr10:128505756-128509942 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017876	protein coding gene	Chr10:132434969-132439000 (-)
A/J	MGP_AJ_G0017851	protein coding gene	Chr10:127117655-127121686 (-)
AKR/J	MGP_AKRJ_G0017814	protein coding gene	Chr10:130835941-130839972 (-)
BALB/cJ	MGP_BALBcJ_G0017815	protein coding gene	Chr10:127485503-127489534 (-)
C3H/HeJ	MGP_C3HHeJ_G0017638	protein coding gene	Chr10:131002717-131006748 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018270	protein coding gene	Chr10:136911920-136915951 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015948	protein coding gene	Chr10:121034428-121038465 (-)
CAST/EiJ	MGP_CASTEiJ_G0017199	protein coding gene	Chr10:131724220-131728250 (-)
CBA/J	MGP_CBAJ_G0017608	protein coding gene	Chr10:142489650-142493681 (-)
DBA/2J	MGP_DBA2J_G0017714	protein coding gene	Chr10:126179153-126183184 (-)
FVB/NJ	MGP_FVBNJ_G0017709	protein coding gene	Chr10:125094542-125098573 (-)
LP/J	MGP_LPJ_G0017788	protein coding gene	Chr10:133027279-133031310 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017737	protein coding gene	Chr10:145063879-145067910 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018310	protein coding gene	Chr10:130940286-130944317 (-)
PWK/PhJ	MGP_PWKPhJ_G0016984	protein coding gene	Chr10:126434227-126438258 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016773	protein coding gene	Chr10:130053490-130057518 (-)
WSB/EiJ	MGP_WSBEiJ_G0017258	protein coding gene	Chr10:131161078-131165109 (-)

Human Ortholog

SUOX, sulfite oxidase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SUOX, sulfite oxidase
Links

HGNC:11460

NCBI Gene ID: 6821

neXtProt AC: NX_P51687

UniProt: P51687
Chr Location

12q13.2; chr12:55997180-56006641 (+) GRCh38

MGI Vertebrate Homology

Suox stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SUOX
Gene Tree

Suox

Diseases

2 with human SUOX associations

				Human Disease	Mouse Models
				inherited metabolic disorder IDs inherited metabolic disorder DOID:655 MESH:D008661 NCI:C34816 UMLS_CUI:C0025521
				isolated sulfite oxidase deficiency IDs isolated sulfite oxidase deficiency DOID:0111270 ICD10CM:E72.19 MESH:C538141 OMIM:272300 ORDO:99731 UMLS_CUI:C0268624 UMLS_CUI:C2931746

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

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All GO Annotations

17
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

93
cDNA Data

49
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase suox

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All Sequences

43
RefSeq

2
UniProt

1
CCDS

CCDS24285.1

Ensembl

ENSMUSG00000049858 (Evidence)
NCBI Gene

211389

			Length	Strain/Species	Flank
genomic	211389	NCBI Gene Model \| MGI Sequence Detail	4032	C57BL/6J	± kb
transcript	NM_173733	RefSeq \| MGI Sequence Detail	2349	Not Specified
polypeptide	Q8R086	UniProt \| EBI \| MGI Sequence Detail	546	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015833 sulfite oxidase, mitochondrial

(term hierarchy)
EC

1.8.3.1
InterPro Domains

IPR018506 Cytochrome b5, heme-binding site

IPR001199 Cytochrome b5-like heme/steroid binding domain

IPR036400 Cytochrome b5-like heme/steroid binding domain superfamily

IPR008335 Eukaryotic molybdopterin oxidoreductase

IPR014756 Immunoglobulin E-set

IPR005066 Moybdenum cofactor oxidoreductase, dimerisation

IPR000572 Oxidoreductase, molybdopterin-binding domain

IPR036374 Oxidoreductase, molybdopterin-binding domain superfamily

IPR022407 Oxidoreductase, molybdopterin binding site
GlyGen

Q8R086 1 site, 1 O-linked glycan (1 site)

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All nucleic 50

cDNA 49

Primer pair 1

Microarray probesets 3

Summaries

All 39

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 5
Earliest

J:86816 Mootha VK, et al., Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell. 2003 Nov 26;115(5):629-40
Latest

J:348785 Zhang D, et al., Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos. J Cell Physiol. 2024 Mar 26;

TSS for Suox:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99922	Chr10:128509765-128509794 (-)	7 bp
Tssr99921	Chr10:128509738-128509757 (-)	39 bp
Tssr99920	Chr10:128508168-128508178 (-)	1,614 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24