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Plekhg6 Gene Detail
Summary
  • Symbol
    Plekhg6
  • Name
    pleckstrin homology domain containing, family G (with RhoGef domain) member 6
  • Synonyms
    LOC213522, MGC:30363
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682298
    NCBI Gene: 213522
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:125339623-125357756 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    579 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2682298
 protein coding gene Chr6:125339614-125358578 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031297
 protein coding gene Chr6:128711829-128730751 (-)
A/J MGP_AJ_G0031268
 protein coding gene Chr6:123851417-123870091 (-)
AKR/J MGP_AKRJ_G0031196
 protein coding gene Chr6:127226544-127246961 (-)
BALB/cJ MGP_BALBcJ_G0031275
 protein coding gene Chr6:123446252-123465115 (-)
C3H/HeJ MGP_C3HHeJ_G0030999
 protein coding gene Chr6:127302342-127321497 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031732
 protein coding gene Chr6:132112482-132133421 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030380
 protein coding gene Chr6:127522358-127540916 (-)
CBA/J MGP_CBAJ_G0030960
 protein coding gene Chr6:137158158-137176348 (-)
DBA/2J MGP_DBA2J_G0031116
 protein coding gene Chr6:122777868-122796281 (-)
FVB/NJ MGP_FVBNJ_G0031065
 protein coding gene Chr6:121693305-121712711 (-)
LP/J MGP_LPJ_G0031196
 protein coding gene Chr6:128871531-128891098 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031104
 protein coding gene Chr6:141193238-141211597 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031767
 protein coding gene Chr6:127139163-127158795 (-)
PWK/PhJ MGP_PWKPhJ_G0030095
 protein coding gene Chr6:121028015-121047606 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029924
 protein coding gene Chr6:125217291-125238755 (-)
WSB/EiJ MGP_WSBEiJ_G0030465
 protein coding gene Chr6:127515109-127533062 (-)



Homology
more
  • Human Ortholog
    PLEKHG6, pleckstrin homology and RhoGEF domain containing G6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHG6, pleckstrin homology and RhoGEF domain containing G6
  • Synonyms
    ARHGEF46, MyoGEF
  • Links
    NCBI Gene ID: 55200
    neXtProt AC: NX_Q3KR16
    UniProt: Q3KR16

  • Chr Location
    12p13.31; chr12:6310332-6328506 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    5
  • cDNA Data
    15
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038167 Ensembl Gene Model | MGI Sequence Detail 18134 C57BL/6J ±  kb
transcript ENSMUST00000042647 Ensembl | MGI Sequence Detail 3299 Not Applicable  
polypeptide ENSMUSP00000037004 Ensembl | MGI Sequence Detail 787 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
less
MGI:2685001
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:84356 Yoshizawa M, et al., Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain. Gene Expr Patterns. 2003 Jun;3(3):375-81
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory