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Ndfip1 Gene Detail
Summary
  • Symbol
    Ndfip1
  • Name
    Nedd4 family interacting protein 1
  • Synonyms
    0610010M22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929601
    NCBI Gene: 65113
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:38551960-38598250 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 20.32 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1158 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929601
 protein coding gene Chr18:38543449-38598356 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024364
 protein coding gene Chr18:36883822-36930476 (+)
A/J MGP_AJ_G0024331
 protein coding gene Chr18:35603970-35650802 (+)
AKR/J MGP_AKRJ_G0024300
 protein coding gene Chr18:36560993-36606485 (+)
BALB/cJ MGP_BALBcJ_G0024331
 protein coding gene Chr18:35666450-35712224 (+)
C3H/HeJ MGP_C3HHeJ_G0024097
 protein coding gene Chr18:36637707-36692455 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024773
 protein coding gene Chr18:38193451-38239907 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022212
 protein coding gene Chr18:35610823-35655103 (+)
CAST/EiJ MGP_CASTEiJ_G0023572
 protein coding gene Chr18:36602187-36656721 (+)
CBA/J MGP_CBAJ_G0024067
 protein coding gene Chr18:39318912-39364381 (+)
DBA/2J MGP_DBA2J_G0024197
 protein coding gene Chr18:35192872-35240049 (+)
FVB/NJ MGP_FVBNJ_G0024163
 protein coding gene Chr18:34914112-34961036 (+)
LP/J MGP_LPJ_G0024281
 protein coding gene Chr18:36930808-36976281 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024194
 protein coding gene Chr18:40559639-40609617 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024822
 protein coding gene Chr18:36442131-36487509 (+)
PWK/PhJ MGP_PWKPhJ_G0023316
 protein coding gene Chr18:35422678-35476128 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023121
 protein coding gene Chr18:36659388-36715545 (+)
WSB/EiJ MGP_WSBEiJ_G0023635
 protein coding gene Chr18:36346132-36392650 (+)



Homology
more
  • Human Ortholog
    NDFIP1, Nedd4 family interacting protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDFIP1, Nedd4 family interacting protein 1
  • Synonyms
    N4WBP5
  • Links
    NCBI Gene ID: 80762
    neXtProt AC: NX_Q9BT67
    UniProt: Q9BT67

  • Chr Location
    5q31.3; chr5:142108779-142154440 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 5 alleles in 6 genetic backgrounds
    14 phenotypes from multigenic genotypes
    2 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele develop severe inflammation of the skin and lung due to T-cell hyperactivation and abnormal T-helper 2 physiology, and die prematurely. Mice homozygous for a null allele exhibit hypersensitivity of dopaminergic neurons to iron toxicity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    889
  • Tissues
    41
  • cDNA Data
    291
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 65113 NCBI Gene Model | MGI Sequence Detail 46291 C57BL/6J ±  kb
    transcript NM_001355749 RefSeq | MGI Sequence Detail 1812 C57BL/6  
    polypeptide Q8R0W6 UniProt | EBI | MGI Sequence Detail 221 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 295
      cDNA 294
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1918924
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 30
    • Earliest
      J:65663 Jolliffe CN, et al., Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase nedd4. Biochem J. 2000 Nov 1;351 Pt 3:557-65
    • Latest
      J:334630 Hsu WL, et al., Identification of Ndfip1 as a novel negative regulator for spatial memory formation associated with increased ubiquitination of Beclin 1 and PTEN. PLoS One. 2023;18(4):e0283908
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory