Timd2 MGI Mouse Gene Detail - MGI:2159681 - T cell immunoglobulin and mucin domain containing 2

Symbol

Timd2
Name

T cell immunoglobulin and mucin domain containing 2
Synonyms

Tim2, TIM-2

Feature Type

protein coding gene
IDs

MGI:2159681
NCBI Gene: 171284
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:46559787-46597888 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 28.05 cM
Mapping Data

2 experiments

SNPs within 2kb

1707 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2159681	protein coding gene	Chr11:46559787-46597934 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018199	protein coding gene	Chr11:45558638-45648725 (-)
A/J	MGP_AJ_G0018171	protein coding gene	Chr11:43799995-43871346 (-)
AKR/J	MGP_AKRJ_G0018137	protein coding gene	Chr11:45130068-45180117 (-)
BALB/cJ	MGP_BALBcJ_G0018140	protein coding gene	Chr11:43952543-44030816 (-)
C3H/HeJ	MGP_C3HHeJ_G0017954	protein coding gene	Chr11:45109650-45201749 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018594	protein coding gene	Chr11:46963527-47013446 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016249	protein coding gene	Chr11:41764618-41802140 (-)
CAST/EiJ	MGP_CASTEiJ_G0017517	protein coding gene	Chr11:45300203-45340505 (-)
CBA/J	MGP_CBAJ_G0017926	protein coding gene	Chr11:49097748-49189097 (-)
DBA/2J	MGP_DBA2J_G0018036	protein coding gene	Chr11:43598303-43644739 (-)
FVB/NJ	MGP_FVBNJ_G0018030	protein coding gene	Chr11:43262987-43307263 (-)
LP/J	MGP_LPJ_G0018108	protein coding gene	Chr11:45828247-45907426 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018054	protein coding gene	Chr11:50667162-50718152 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018633	protein coding gene	Chr11:45268168-45306441 (-)
PWK/PhJ	MGP_PWKPhJ_G0017297	protein coding gene	Chr11:43695635-43736822 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017090	protein coding gene	Chr11:45084671-45127694 (-)
WSB/EiJ	MGP_WSBEiJ_G0017567	protein coding gene	Chr11:44937283-45012200 (-)

Human Ortholog

HAVCR1, hepatitis A virus cellular receptor 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HAVCR1, hepatitis A virus cellular receptor 1
Synonyms

CD365, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1
Links

HGNC:17866

NCBI Gene ID: 26762

neXtProt AC: NX_Q96D42

UniProt: Q96D42
Chr Location

5q33.3; chr5:157026742-157069407 (-) GRCh38

MGI Vertebrate Homology

Timd2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: HAVCR1
Gene Tree

Timd2

Diseases

1 with human HAVCR1 associations

				Human Disease	Mouse Models
				atopic dermatitis IDs atopic dermatitis DOID:3310 EFO:0000274 ICD10CM:L20 MESH:D003876 OMIM:603165 OMIM:PS603165 UMLS_CUI:C0011615

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

3
Genomic Mutations

1 involving Timd2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

21 strains or lines available

Mice homozygous for a null allele exhibit an exacerbated inflammatory response.

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

756
Tissues

20
cDNA Data

90
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

63
RefSeq

10
UniProt

3
CCDS

CCDS24582.1

Ensembl

ENSMUSG00000040413 (Evidence)
NCBI Gene

171284

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040413	Ensembl Gene Model \| MGI Sequence Detail	38102	C57BL/6J	± kb
transcript	ENSMUST00000169584	Ensembl \| MGI Sequence Detail	2926	Not Applicable
polypeptide	ENSMUSP00000131540	Ensembl \| MGI Sequence Detail	305	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016926 T-cell immunoglobulin and mucin domain-containing protein 2

(term hierarchy)
PDB

2OR7
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain

IPR052331 T-cell immunoglobulin and mucin domain-containing protein
GlyGen

Q8R183 2 sites

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All nucleic 93

cDNA 90

Primer pair 2

Other 1

Microarray probesets 6

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MGI:2144392, MGI:2144396, MGI:2144635, MGI:3034262

Summaries

All 42

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 8
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:344223 Zhang W, et al., NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance. Cell Rep. 2023 Dec 26;42(12):113531

TSS for Timd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr107619	Chr11:46597924-46597939 (-)	-44 bp
Tssr3476	Chr11:46597915-46597918 (-)	-29 bp
Tssr107618	Chr11:46597887-46597904 (-)	-8 bp
Tssr107617	Chr11:46589876-46589902 (-)	7,999 bp
Tssr107616	Chr11:46589646-46589662 (-)	8,234 bp
Tssr107615	Chr11:46589435-46589450 (-)	8,445 bp
Tssr107614	Chr11:46581133-46581147 (-)	16,748 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24