Dync1li1 MGI Mouse Gene Detail - MGI:2135610 - dynein cytoplasmic 1 light intermediate chain 1

Symbol

Dync1li1
Name

dynein cytoplasmic 1 light intermediate chain 1
Synonyms

1110053F02Rik, Dlic1, Dnclic1, LIC-1, MGC:32416

Feature Type

protein coding gene
IDs

MGI:2135610
NCBI Gene: 235661
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr9:114517899-114552856 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 64.96 cM
Mapping Data

3 experiments

SNPs within 2kb

1178 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2135610	protein coding gene	Chr9:114517858-114553370 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035392	protein coding gene	Chr9:117143842-117183149 (+)
A/J	MGP_AJ_G0035372	protein coding gene	Chr9:112852144-112888822 (+)
AKR/J	MGP_AKRJ_G0035305	protein coding gene	Chr9:115723846-115759151 (+)
BALB/cJ	MGP_BALBcJ_G0035368	protein coding gene	Chr9:112658979-112696186 (+)
C3H/HeJ	MGP_C3HHeJ_G0035076	protein coding gene	Chr9:116224763-116261467 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035891	protein coding gene	Chr9:120346959-120387406 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032774	protein coding gene	Chr9:110150717-110188328 (+)
CAST/EiJ	MGP_CASTEiJ_G0034381	protein coding gene	Chr9:116092145-116132297 (+)
CBA/J	MGP_CBAJ_G0035043	protein coding gene	Chr9:124855223-124901692 (+)
DBA/2J	MGP_DBA2J_G0035202	protein coding gene	Chr9:112326659-112362401 (+)
FVB/NJ	MGP_FVBNJ_G0035149	protein coding gene	Chr9:111152216-111187977 (+)
LP/J	MGP_LPJ_G0035281	protein coding gene	Chr9:117481129-117518462 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035190	protein coding gene	Chr9:126088913-126129202 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035910	protein coding gene	Chr9:116100115-116136739 (+)
PWK/PhJ	MGP_PWKPhJ_G0034087	protein coding gene	Chr9:112632094-112670176 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033921	protein coding gene	Chr9:116141291-116179691 (+)
WSB/EiJ	MGP_WSBEiJ_G0034501	protein coding gene	Chr9:115975631-116017840 (+)

Human Ortholog

DYNC1LI1, dynein cytoplasmic 1 light intermediate chain 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DYNC1LI1, dynein cytoplasmic 1 light intermediate chain 1
Synonyms

DLC-A, DLIC-1, DNCLI1, LIC1
Links

HGNC:18745

NCBI Gene ID: 51143

neXtProt AC: NX_Q9Y6G9

UniProt: Q9Y6G9
Chr Location

3p22.3; chr3:32525974-32570858 (-) GRCh38

MGI Vertebrate Homology

Dync1li1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DYNC1LI1
Gene Tree

Dync1li1

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Phenotype Summary

25 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

31
Chemically induced (ENU)

1
Endonuclease-mediated

4
Gene trapped

22
Targeted

4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

57 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced allele exhibit increased anxiety-related response, increased dendrite length, increased neuron migration, and decreased lysosome trafficking.

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All GO Annotations

43
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

1
cDNA Data

84
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DYNC1LI1

Xenbase dync1li1

ZFIN dync1li1

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All Sequences

64
RefSeq

2
UniProt

4
CCDS

CCDS23595.1

Ensembl

ENSMUSG00000032435 (Evidence)
NCBI Gene

235661

			Length	Strain/Species	Flank
genomic	235661	NCBI Gene Model \| MGI Sequence Detail	34958	C57BL/6J	± kb
transcript	NM_146229	RefSeq \| MGI Sequence Detail	2046	C57BL/6
polypeptide	Q8R1Q8	UniProt \| EBI \| MGI Sequence Detail	523	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006773 cytoplasmic dynein 1 light intermediate chain 1

(term hierarchy)
InterPro Domains

IPR008467 Dynein 1 light intermediate chain

IPR022780 Dynein family light intermediate chain

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q8R1Q8 1 site, 1 O-linked glycan (1 site)

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All nucleic 84

cDNA 84

Microarray probesets 3

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MGI:1916070

Summaries

All 52

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 19
Earliest

J:63816 Nolan PM, et al., A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet. 2000 Aug;25(4):440-3
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dync1li1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87568	Chr9:114517797-114517808 (+)	-96 bp
Tssr87569	Chr9:114517812-114517846 (+)	-70 bp
Tssr87570	Chr9:114517850-114517881 (+)	-33 bp
Tssr87571	Chr9:114517882-114517887 (+)	-14 bp
Tssr87572	Chr9:114517888-114517901 (+)	-4 bp
Tssr87573	Chr9:114517904-114517914 (+)	10 bp
Tssr87574	Chr9:114517919-114517933 (+)	27 bp
Tssr87575	Chr9:114517934-114517945 (+)	41 bp
Tssr87576	Chr9:114518947-114518952 (+)	1,051 bp
Tssr87577	Chr9:114551378-114551383 (+)	33,482 bp
Tssr87578	Chr9:114552573-114552588 (+)	34,682 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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