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Coq6 Gene Detail
Summary
  • Symbol
    Coq6
  • Name
    coenzyme Q6 monooxygenase
  • Synonyms
    5930427M12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924408
    NCBI Gene: 217707
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:84408530-84420570 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 39.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    404 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924408
 protein coding gene Chr12:84408431-84420570 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019934
 protein coding gene Chr12:85065298-85077432 (+)
A/J MGP_AJ_G0019891
 protein coding gene Chr12:81845340-81857531 (+)
AKR/J MGP_AKRJ_G0019867
 protein coding gene Chr12:84063703-84075640 (+)
BALB/cJ MGP_BALBcJ_G0019871
 protein coding gene Chr12:82179003-82191016 (+)
C3H/HeJ MGP_C3HHeJ_G0019677
 protein coding gene Chr12:84527099-84538903 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020322
 protein coding gene Chr12:87510371-87522815 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017940
 protein coding gene Chr12:78747958-78759824 (+)
CAST/EiJ MGP_CASTEiJ_G0019226
 protein coding gene Chr12:79480152-79492026 (+)
CBA/J MGP_CBAJ_G0019648
 protein coding gene Chr12:90891745-90903823 (+)
DBA/2J MGP_DBA2J_G0019763
 protein coding gene Chr12:81374438-81386582 (+)
FVB/NJ MGP_FVBNJ_G0019749
 protein coding gene Chr12:80326045-80338062 (+)
LP/J MGP_LPJ_G0019835
 protein coding gene Chr12:84943469-84955602 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019788
 protein coding gene Chr12:93802892-93818756 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020356
 protein coding gene Chr12:83657398-83669503 (+)
PWK/PhJ MGP_PWKPhJ_G0018990
 protein coding gene Chr12:75861987-75874274 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018785
 protein coding gene Chr12:78146153-78158185 (+)
WSB/EiJ MGP_WSBEiJ_G0019278
 protein coding gene Chr12:84368624-84382065 (+)



Homology
more
  • Human Ortholog
    COQ6, coenzyme Q6, monooxygenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COQ6, coenzyme Q6, monooxygenase
  • Synonyms
    CGI-10, CGI10, COQ10D6
  • Links
    NCBI Gene ID: 51004
    neXtProt AC: NX_Q9Y2Z9
    UniProt: Q9Y2Z9

  • Chr Location
    14q24.3; chr14:73949926-73963670 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human COQ6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 3 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are embryonic lethal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    99
  • cDNA Data
    55
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 217707 NCBI Gene Model | MGI Sequence Detail 12041 C57BL/6J ±  kb
    transcript NM_172582 RefSeq | MGI Sequence Detail 1602 Not Specified  
    polypeptide Q8R1S0 UniProt | EBI | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000005755 ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
      (term hierarchy)
    • EC
      1.14.13.-
    • InterPro Domains
      IPR002938 FAD-binding domain
      IPR036188 FAD/NAD(P)-binding domain superfamily
      IPR010971 Ubiquinone biosynthesis hydroxylase UbiH/COQ6
      IPR018168 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6, conserved site
      IPR000689 Ubiquinone biosynthesis monooxygenase COQ6
      IPR051205 Ubiquinone biosynthesis monooxygenase UbiH/COQ6
    • GlyGen
      Q8R1S0 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 55
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory