About   Help   FAQ
Ccdc80 Gene Detail
Summary
  • Symbol
    Ccdc80
  • Name
    coiled-coil domain containing 80
  • Synonyms
    2610001E17Rik, DRO1, Ssg1, Urb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915146
    NCBI Gene: 67896
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:44913770-44948287 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 29.39 cM, cytoband B5
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    952 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915146
 protein coding gene Chr16:44913765-44948440 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022847
 protein coding gene Chr16:43870814-43908130 (+)
A/J MGP_AJ_G0022812
 protein coding gene Chr16:41894830-41931444 (+)
AKR/J MGP_AKRJ_G0022784
 protein coding gene Chr16:43273086-43311905 (+)
BALB/cJ MGP_BALBcJ_G0022813
 protein coding gene Chr16:41899349-41934697 (+)
C3H/HeJ MGP_C3HHeJ_G0022577
 protein coding gene Chr16:43430222-43468007 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023260
 protein coding gene Chr16:44860946-44898904 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020774
 protein coding gene Chr16:42297983-42332027 (+)
CAST/EiJ MGP_CASTEiJ_G0022102
 protein coding gene Chr16:43614217-43652593 (+)
CBA/J MGP_CBAJ_G0022548
 protein coding gene Chr16:46769468-46806235 (+)
DBA/2J MGP_DBA2J_G0022680
 protein coding gene Chr16:41632870-41671310 (+)
FVB/NJ MGP_FVBNJ_G0022655
 protein coding gene Chr16:41563618-41597803 (+)
LP/J MGP_LPJ_G0022748
 protein coding gene Chr16:43602819-43642107 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022674
 protein coding gene Chr16:46171535-46211192 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023275
 protein coding gene Chr16:43296443-43332922 (+)
PWK/PhJ MGP_PWKPhJ_G0021842
 protein coding gene Chr16:42006001-42041257 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021673
 protein coding gene Chr16:43215644-43250664 (+)
WSB/EiJ MGP_WSBEiJ_G0022147
 protein coding gene Chr16:43385350-43421570 (+)



Homology
more
  • Human Ortholog
    CCDC80, coiled-coil domain containing 80
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCDC80, coiled-coil domain containing 80
  • Synonyms
    CL2, DRO1, LINC01279, okuribin, SSG1, URB
  • Links
    NCBI Gene ID: 151887
    neXtProt AC: NX_Q76M96
    UniProt: Q76M96

  • Chr Location
    3q13.2; chr3:112596797-112649530 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 4 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased adiposity, hyperglycemia, glucose intolerance, impaired insulin secretion, and altered energy intake and expenditure when fed a high-fat diet. Mice homozygous for a different null allele develop thyroid adenomas and ovarian carcinomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    46
  • cDNA Data
    107
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67896 NCBI Gene Model | MGI Sequence Detail 34518 C57BL/6J ±  kb
    transcript NM_026439 RefSeq | MGI Sequence Detail 3690 C57BL/6  
    polypeptide Q8R2G6 UniProt | EBI | MGI Sequence Detail 949 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005104 coiled-coil domain-containing protein 80
      (term hierarchy)
    • InterPro Domains
      IPR025232 Domain of unknown function DUF4174
    • GlyGen
      Q8R2G6 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 107
      Primer pair 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory