Ntmt1 MGI Mouse Gene Detail - MGI:1913867 - N-terminal Xaa-Pro-Lys N-methyltransferase 1

Symbol

Ntmt1
Name

N-terminal Xaa-Pro-Lys N-methyltransferase 1
Synonyms

2610205E22Rik, Mettl11a

Feature Type

protein coding gene
IDs

MGI:1913867
NCBI Gene: 66617
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:30697838-30713045 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 21.74 cM
Mapping Data

2 experiments

SNPs within 2kb

561 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913867	protein coding gene	Chr2:30697576-30713045 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025573	protein coding gene	Chr2:29085493-29101398 (+)
A/J	MGP_AJ_G0025551	protein coding gene	Chr2:27906519-27924218 (+)
AKR/J	MGP_AKRJ_G0025520	protein coding gene	Chr2:28857945-28875977 (+)
BALB/cJ	MGP_BALBcJ_G0025547	protein coding gene	Chr2:28044055-28059987 (+)
C3H/HeJ	MGP_C3HHeJ_G0025308	protein coding gene	Chr2:28782637-28799352 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025992	protein coding gene	Chr2:30037951-30056984 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023400	protein coding gene	Chr2:26674755-26689998 (+)
CAST/EiJ	MGP_CASTEiJ_G0024770	protein coding gene	Chr2:28706176-28724688 (+)
CBA/J	MGP_CBAJ_G0025285	protein coding gene	Chr2:31082475-31104164 (+)
DBA/2J	MGP_DBA2J_G0025418	protein coding gene	Chr2:27689643-27705078 (+)
FVB/NJ	MGP_FVBNJ_G0025381	protein coding gene	Chr2:27521807-27537935 (+)
LP/J	MGP_LPJ_G0025504	protein coding gene	Chr2:28994829-29012577 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025411	protein coding gene	Chr2:30885406-30901202 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026050	protein coding gene	Chr2:28768821-28784223 (+)
PWK/PhJ	MGP_PWKPhJ_G0024517	protein coding gene	Chr2:27551739-27567557 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024317	protein coding gene	Chr2:28901062-28917863 (+)
WSB/EiJ	MGP_WSBEiJ_G0024838	protein coding gene	Chr2:28931787-28951136 (+)

Human Ortholog

NTMT1, N-terminal Xaa-Pro-Lys N-methyltransferase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NTMT1, N-terminal Xaa-Pro-Lys N-methyltransferase 1
Synonyms

AD-003, C9orf32, HOMT1A, METTL11A, NRMT, NRMT1, NTM1A
Links

HGNC:23373

NCBI Gene ID: 28989

neXtProt AC: NX_Q9BV86

UniProt: Q9BV86
Chr Location

9q34.11; chr9:129608872-129636135 (+) GRCh38

MGI Vertebrate Homology

Ntmt1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NTMT1
Protein SuperFamily

DUF858_MeTrfase_lik
Gene Tree

Ntmt1

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Phenotype Summary

21 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (ENU)

1
Gene trapped

28
Targeted

3
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit preweaning lethality and premature death associated with premature aging, decreased body size and weight, skin thinning, liver degeneration, increased sensitivity to oxidative stress and female infertility.

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All GO Annotations

29
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

53
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ntmt1

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All Sequences

105
RefSeq

20
UniProt

6
CCDS

CCDS15886.1

Ensembl

ENSMUSG00000026857 (Evidence)
NCBI Gene

66617

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026857	Ensembl Gene Model \| MGI Sequence Detail	15208	C57BL/6J	± kb
transcript	ENSMUST00000041830	Ensembl \| MGI Sequence Detail	1387	Not Applicable
polypeptide	ENSMUSP00000035303	Ensembl \| MGI Sequence Detail	223	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000010343 methyltransferase-like protein 11A

(term hierarchy)
EC

2.1.1.244
InterPro Domains

IPR008576 Alpha-N-methyltransferase NTM1

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
GlyGen

Q8R2U4 1 site, 1 N-linked glycan (1 site)

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All nucleic 53

cDNA 53

Microarray probesets 5

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MGI:2139140, MGI:2145326

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:354852 Singh K, et al., The IgLON family of cell adhesion molecules expressed in developing neural circuits ensure the proper functioning of the sensory system in mice. Sci Rep. 2024 Sep 30;14(1):22593

TSS for Ntmt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17138	Chr2:30697382-30697403 (+)	-445 bp
Tssr17139	Chr2:30697940-30698011 (+)	138 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24