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Abhd6 Gene Detail
Summary
  • Symbol
    Abhd6
  • Name
    abhydrolase domain containing 6
  • Synonyms
    0610041D24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913332
    NCBI Gene: 66082
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:14413010-14466871 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 4.69 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1878 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913332
 protein coding gene Chr14:14413000-14466885 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020986
 protein coding gene Chr14:334522-392218 (+)
A/J MGP_AJ_G0020934
 protein coding gene Chr14:317063-371555 (+)
AKR/J MGP_AKRJ_G0020911
 protein coding gene Chr14:310376-370958 (+)
BALB/cJ MGP_BALBcJ_G0020936
 protein coding gene Chr14:307773-368193 (+)
C3H/HeJ MGP_C3HHeJ_G0020721
 protein coding gene Chr14:317991-375580 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021370
 protein coding gene Chr14:343445-404665 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018939
 protein coding gene Chr14:1243414-1294922 (+)
CAST/EiJ MGP_CASTEiJ_G0020243
 protein coding gene Chr14:317202-376009 (+)
CBA/J MGP_CBAJ_G0020687
 protein coding gene Chr14:340840-402919 (+)
DBA/2J MGP_DBA2J_G0020810
 protein coding gene Chr14:295673-348257 (+)
FVB/NJ MGP_FVBNJ_G0020792
 protein coding gene Chr14:298639-352055 (+)
LP/J MGP_LPJ_G0020887
 protein coding gene Chr14:312603-369551 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020818
 protein coding gene Chr14:337839-405051 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021403
 protein coding gene Chr14:321719-377392 (+)
PWK/PhJ MGP_PWKPhJ_G0019995
 protein coding gene Chr14:319418-374563 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019816
 protein coding gene Chr14:326984-381423 (+)
WSB/EiJ MGP_WSBEiJ_G0020301
 protein coding gene Chr14:317776-372416 (+)



Homology
more
  • Human Ortholog
    ABHD6, abhydrolase domain containing 6, acylglycerol lipase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABHD6, abhydrolase domain containing 6, acylglycerol lipase
  • Links
    NCBI Gene ID: 57406
    neXtProt AC: NX_Q9BV23
    UniProt: Q9BV23

  • Chr Location
    3p14.3; chr3:58237532-58295693 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show increased glucose-stimulated insulin secretion from islets which exhibit elevated monoacylglycerol content in response to glucose.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    47
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025277 Ensembl Gene Model | MGI Sequence Detail 53862 C57BL/6J ±  kb
    transcript ENSMUST00000166497 Ensembl | MGI Sequence Detail 2226 Not Applicable  
    polypeptide ENSMUSP00000129169 Ensembl | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 47

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138123, MGI:2145774
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory