Plaat3 MGI Mouse Gene Detail - MGI:2179715 - phospholipase A and acyltransferase 3

Symbol

Plaat3
Name

phospholipase A and acyltransferase 3
Synonyms

Hrasls3, Pla2g16

Feature Type

protein coding gene
IDs

MGI:2179715
NCBI Gene: 225845
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr19:7534824-7565910 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 5.33 cM
Mapping Data

1 experiment

SNPs within 2kb

898 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2179715	protein coding gene	Chr19:7534824-7565914 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024794	protein coding gene	Chr19:4704739-4737845 (+)
A/J	MGP_AJ_G0024761	protein coding gene	Chr19:4352331-4384017 (+)
AKR/J	MGP_AKRJ_G0024734	protein coding gene	Chr19:4473974-4505871 (+)
BALB/cJ	MGP_BALBcJ_G0024761	protein coding gene	Chr19:4450670-4483865 (+)
C3H/HeJ	MGP_C3HHeJ_G0024528	protein coding gene	Chr19:4609238-4640933 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025207	protein coding gene	Chr19:4805495-4835584 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022641	protein coding gene	Chr19:4243204-4274546 (+)
CAST/EiJ	MGP_CASTEiJ_G0024001	protein coding gene	Chr19:4522998-4554427 (+)
CBA/J	MGP_CBAJ_G0024501	protein coding gene	Chr19:4869530-4901092 (+)
DBA/2J	MGP_DBA2J_G0024628	protein coding gene	Chr19:4300379-4331640 (+)
FVB/NJ	MGP_FVBNJ_G0024593	protein coding gene	Chr19:4342806-4374018 (+)
LP/J	MGP_LPJ_G0024714	protein coding gene	Chr19:4553926-4585330 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024623	protein coding gene	Chr19:4769980-4805198 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025255	protein coding gene	Chr19:4643600-4675201 (+)
PWK/PhJ	MGP_PWKPhJ_G0023747	protein coding gene	Chr19:4366757-4398482 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023551	protein coding gene	Chr19:4438132-4469611 (+)
WSB/EiJ	MGP_WSBEiJ_G0024063	protein coding gene	Chr19:4534465-4565208 (+)

Human Ortholog

PLAAT3, phospholipase A and acyltransferase 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLAAT3, phospholipase A and acyltransferase 3
Synonyms

AdPLA, FPLD9, HRASLS3, H-REV107, HREV107, H-REV107-1, HREV107-1, HREV107-3, HRSL3, PLA2G16, PLAAT-3
Links

HGNC:17825

NCBI Gene ID: 11145

neXtProt AC: NX_P53816

UniProt: P53816
Chr Location

11q12.3-q13.1; chr11:63573195-63616927 (-) GRCh38

MGI Vertebrate Homology

Plaat3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PLAAT3
Gene Tree

Plaat3

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Phenotype Summary

34 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

151
Endonuclease-mediated

3
Gene trapped

145
Targeted

3
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased lipolysis, decreased susceptibility to diet- or leptin deficiency-induced obesity, hepatic steatosis and altered glucose homeostasis.

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All GO Annotations

45
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

29

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plaat3

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All Sequences

46
RefSeq

6
UniProt

2
CCDS

CCDS29528.1

Ensembl

ENSMUSG00000060675 (Evidence)
NCBI Gene

225845

			Length	Strain/Species	Flank
genomic	ENSMUSG00000060675	Ensembl Gene Model \| MGI Sequence Detail	31087	C57BL/6J	± kb
transcript	ENSMUST00000136465	Ensembl \| MGI Sequence Detail	3048	Not Applicable
polypeptide	ENSMUSP00000119403	Ensembl \| MGI Sequence Detail	168	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008747 phospholipase A and acyltransferase 3

(term hierarchy)
EC

2.3.1.-, 3.1.1.32, 3.1.1.4
InterPro Domains

IPR051496 H-rev107 Phospholipase/Acyltransferase

IPR007053 LRAT domain

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All nucleic 29

cDNA 29

Microarray probesets 3

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MGI:2147787, MGI:6286251

Summaries

All 47

Gene Ontology 13

Phenotypes 14
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Plaat3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154766	Chr19:7534817-7534830 (+)	0 bp
Tssr154767	Chr19:7534838-7534862 (+)	26 bp
Tssr154768	Chr19:7534865-7534878 (+)	48 bp
Tssr154769	Chr19:7535007-7535054 (+)	207 bp
Tssr154770	Chr19:7537007-7537030 (+)	2,195 bp
Tssr154771	Chr19:7539093-7539111 (+)	4,278 bp
Tssr154772	Chr19:7556497-7556511 (+)	21,680 bp
Tssr154773	Chr19:7558700-7558712 (+)	23,882 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24