Rbm12 MGI Mouse Gene Detail - MGI:1922960 - RNA binding motif protein 12

Symbol

Rbm12
Name

RNA binding motif protein 12
Synonyms

5730420G12Rik, 9430070C08Rik, MGC:30712, MGC:38279, SWAN

Feature Type

protein coding gene
IDs

MGI:1922960
NCBI Gene: 75710
Alliance

gene page

Sequence Map

Chr2:155933876-155953847 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 77.35 cM, cytoband H2
Mapping Data

4 experiments

SNPs within 2kb

383 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922960	protein coding gene	Chr2:155933876-155953898 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026757	protein coding gene	Chr2:160949682-160971339 (-)
A/J	MGP_AJ_G0026723	protein coding gene	Chr2:154563072-154583014 (-)
AKR/J	MGP_AKRJ_G0026694	protein coding gene	Chr2:159049084-159069738 (-)
BALB/cJ	MGP_BALBcJ_G0026732	protein coding gene	Chr2:154857921-154877936 (-)
C3H/HeJ	MGP_C3HHeJ_G0026475	protein coding gene	Chr2:159411159-159434202 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027181	protein coding gene	Chr2:165679386-165702770 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024551	protein coding gene	Chr2:148057823-148078218 (-)
CAST/EiJ	MGP_CASTEiJ_G0025936	protein coding gene	Chr2:159738744-159758723 (-)
CBA/J	MGP_CBAJ_G0026452	protein coding gene	Chr2:171700022-171729715 (-)
DBA/2J	MGP_DBA2J_G0026589	protein coding gene	Chr2:153734954-153754984 (-)
FVB/NJ	MGP_FVBNJ_G0026556	protein coding gene	Chr2:152114891-152135791 (-)
LP/J	MGP_LPJ_G0026694	protein coding gene	Chr2:161089953-161111989 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026577	protein coding gene	Chr2:175652856-175675114 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027237	protein coding gene	Chr2:158926320-158946672 (-)
PWK/PhJ	MGP_PWKPhJ_G0025670	protein coding gene	Chr2:153241618-153261848 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025473	protein coding gene	Chr2:157873353-157893092 (-)
WSB/EiJ	MGP_WSBEiJ_G0026006	protein coding gene	Chr2:159814556-159836902 (-)

Human Ortholog

RBM12, RNA binding motif protein 12

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBM12, RNA binding motif protein 12
Synonyms

HRIHFB2091, SCZD19, SWAN
Links

HGNC:9898

NCBI Gene ID: 10137

neXtProt AC: NX_Q9NTZ6

UniProt: Q9NTZ6
Chr Location

20q11.22; chr20:35648925-35664956 (-) GRCh38

MGI Vertebrate Homology

Rbm12 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: RBM12
Gene Tree

Rbm12

Diseases

1 with human RBM12 associations

				Human Disease	Mouse Models
				schizophrenia 19 IDs schizophrenia 19 DOID:0080281 OMIM:617629

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
2 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Chemically induced (ENU)

1
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

87 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU mutation exhibit open neural tube and embryonic growth retardation.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

22
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rbm12

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All Sequences

57
RefSeq

4
UniProt

4
CCDS

CCDS16961.1

Ensembl

ENSMUSG00000089824 (Evidence)
NCBI Gene

75710

			Length	Strain/Species	Flank
genomic	75710	NCBI Gene Model \| MGI Sequence Detail	19972	C57BL/6J	± kb
transcript	NM_029397	RefSeq \| MGI Sequence Detail	6640	C57BL/6
polypeptide	Q8R4X3	UniProt \| EBI \| MGI Sequence Detail	992	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013784 RNA-binding protein 12

(term hierarchy)
PDB

2CQP
InterPro Domains

IPR050666 Epithelial Splicing Regulatory

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR034591 RBM12, RNA recognition motif 1

IPR034594 RBM12, RNA recognition motif 2

IPR034855 RBM12, RNA recognition motif 3

IPR034856 RBM12, RNA recognition motif 4

IPR034854 RBM12, RNA recognition motif 5

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain
GlyGen

Q8R4X3 7 sites, 1 O-linked glycan (7 sites)

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All nucleic 14

cDNA 13

Primer pair 1

Microarray probesets 4

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MGI:1924605, MGI:2139092

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 2
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:186861 Sun M, et al., Multiplex Chromosomal Exome Sequencing Accelerates Identification of ENU-Induced Mutations in the Mouse. G3 (Bethesda). 2012 Jan;2(1):143-50

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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