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Arap3 Gene Detail
Summary
  • Symbol
    Arap3
  • Name
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
  • Synonyms
    Centd3, DRAG1, E030006K04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147274
    NCBI Gene: 106952
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:38105681-38132022 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    636 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147274
 protein coding gene Chr18:38105676-38132583 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024358
 protein coding gene Chr18:36395292-36421442 (-)
A/J MGP_AJ_G0024325
 protein coding gene Chr18:35142319-35168433 (-)
AKR/J MGP_AKRJ_G0024294
 protein coding gene Chr18:36105228-36131305 (-)
BALB/cJ MGP_BALBcJ_G0024325
 protein coding gene Chr18:35208679-35233624 (-)
C3H/HeJ MGP_C3HHeJ_G0024091
 protein coding gene Chr18:36172027-36198720 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024767
 protein coding gene Chr18:37695251-37724332 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022206
 protein coding gene Chr18:35162898-35190817 (-)
CAST/EiJ MGP_CASTEiJ_G0023566
 protein coding gene Chr18:36112287-36138707 (-)
CBA/J MGP_CBAJ_G0024061
 protein coding gene Chr18:38808060-38836355 (-)
DBA/2J MGP_DBA2J_G0024191
 protein coding gene Chr18:34743359-34768963 (-)
FVB/NJ MGP_FVBNJ_G0024157
 protein coding gene Chr18:34452349-34479304 (-)
LP/J MGP_LPJ_G0024275
 protein coding gene Chr18:36458307-36485096 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024188
 protein coding gene Chr18:40061035-40087198 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024816
 protein coding gene Chr18:35970340-35997256 (-)
PWK/PhJ MGP_PWKPhJ_G0023310
 protein coding gene Chr18:34952082-34978769 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023115
 protein coding gene Chr18:36187058-36213388 (-)
WSB/EiJ MGP_WSBEiJ_G0023629
 protein coding gene Chr18:35870594-35898139 (-)



Homology
more
  • Human Ortholog
    ARAP3, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARAP3, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
  • Synonyms
    CENTD3, DRAG1
  • Links
    NCBI Gene ID: 64411
    neXtProt AC: NX_Q8WWN8
    UniProt: Q8WWN8

  • Chr Location
    5q31.3; chr5:141653401-141682230 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 4 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die around E11 exhibiting pallor, embryonic growth arrest, yolk sac and placental abnormalities, and an endothelial cell-autonomous defect in sprouting angiogenesis. Knock-in mice homozygous for a point mutation display similar angiogenesis defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    2
  • cDNA Data
    27
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024451 Ensembl Gene Model | MGI Sequence Detail 26342 C57BL/6J ±  kb
    transcript ENSMUST00000042944 Ensembl | MGI Sequence Detail 5219 Not Applicable  
    polypeptide ENSMUSP00000035662 Ensembl | MGI Sequence Detail 1538 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 27

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2444395
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory