Wasf1 MGI Mouse Gene Detail - MGI:1890563

Symbol

Wasf1
Name

WASP family, member 1
Synonyms

Scar, WAVE, WAVE-1

Feature Type

protein coding gene
IDs

MGI:1890563
NCBI Gene: 83767
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:40759476-40814565 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 22.07 cM
Mapping Data

5 experiments

SNPs within 2kb

1643 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890563	protein coding gene	Chr10:40759471-40814566 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017168	protein coding gene	Chr10:39502307-39566424 (+)
A/J	MGP_AJ_G0017145	protein coding gene	Chr10:38402366-38457910 (+)
AKR/J	MGP_AKRJ_G0017105	protein coding gene	Chr10:38958188-39029837 (+)
BALB/cJ	MGP_BALBcJ_G0017107	protein coding gene	Chr10:38483437-38538759 (+)
C3H/HeJ	MGP_C3HHeJ_G0016928	protein coding gene	Chr10:39282384-39340152 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017566	protein coding gene	Chr10:40712919-40770861 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015262	protein coding gene	Chr10:36364250-36421731 (+)
CAST/EiJ	MGP_CASTEiJ_G0016507	protein coding gene	Chr10:39483996-39539291 (+)
CBA/J	MGP_CBAJ_G0016902	protein coding gene	Chr10:42572741-42630017 (+)
DBA/2J	MGP_DBA2J_G0017007	protein coding gene	Chr10:37916823-37971624 (+)
FVB/NJ	MGP_FVBNJ_G0017002	protein coding gene	Chr10:37415641-37470066 (+)
LP/J	MGP_LPJ_G0017084	protein coding gene	Chr10:39483674-39547093 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017032	protein coding gene	Chr10:43386530-43443744 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017603	protein coding gene	Chr10:38939391-38996586 (+)
PWK/PhJ	MGP_PWKPhJ_G0016287	protein coding gene	Chr10:37806971-37862544 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016071	protein coding gene	Chr10:38777770-38840421 (+)
WSB/EiJ	MGP_WSBEiJ_G0016570	protein coding gene	Chr10:39280994-39341080 (+)

Human Ortholog

WASF1, WASP family member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WASF1, WASP family member 1
Synonyms

NEDALVS, SCAR1, WAVE, WAVE1
Links

HGNC:12732

NCBI Gene ID: 8936

neXtProt AC: NX_Q92558

UniProt: Q92558
Chr Location

6q21; chr6:110099819-110180004 (-) GRCh38

MGI Vertebrate Homology

Wasf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WASF1
Gene Tree

Wasf1

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Phenotype Summary

34 phenotypes from 3 alleles in 2 genetic backgrounds
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

62
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

52
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Wasf1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutation of this gene has been associated with both morphological and functional defects of the central nervous system. Targeted mutagenesis has resulted in mice that display sensorimotor and cognitive defects similar to those exhibited by patients with 3p-syndrome mental retardation.

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All GO Annotations

46
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

872
Tissues

55
cDNA Data

22
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wasf1

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All Sequences

43
RefSeq

8
UniProt

1
CCDS

CCDS23801.1

Ensembl

ENSMUSG00000019831 (Evidence)
NCBI Gene

83767

			Length	Strain/Species	Flank
genomic	83767	NCBI Gene Model \| MGI Sequence Detail	55090	C57BL/6J	± kb
transcript	NM_001379453	RefSeq \| MGI Sequence Detail	2718	ZRU/MplStud
polypeptide	Q8R5H6	UniProt \| EBI \| MGI Sequence Detail	559	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017372 actin-binding protein WASF1

(term hierarchy)
InterPro Domains

IPR028288 SCAR/WAVE family

IPR003124 WH2 domain
GlyGen

Q8R5H6 1 site, 1 O-linked glycan (1 site)

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All nucleic 29

cDNA 23

Primer pair 4

Other 2

Microarray probesets 3

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MGI:2143538, MGI:2143675

Summaries

All 82

Developmental Gene Expression 12

Gene Ontology 16

Phenotypes 27
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:354447 Zhang Y, et al., Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2alpha phosphorylation via protein interactors and actin cytoskeleton. Hum Mol Genet. 2024 Sep 19;33(19):1671-1687

TSS for Wasf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93031	Chr10:40759465-40759479 (+)	-4 bp
Tssr93032	Chr10:40759489-40759504 (+)	21 bp
Tssr93033	Chr10:40759516-40759594 (+)	79 bp
Tssr93034	Chr10:40759616-40759630 (+)	147 bp
Tssr93035	Chr10:40759815-40759858 (+)	361 bp
Tssr93036	Chr10:40807915-40807934 (+)	48,449 bp
Tssr93037	Chr10:40812167-40812202 (+)	52,709 bp
Tssr93038	Chr10:40812395-40812412 (+)	52,928 bp
Tssr93039	Chr10:40814187-40814196 (+)	54,716 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24