Slc17a9 MGI Mouse Gene Detail - MGI:1919107 - solute carrier family 17, member 9

Symbol

Slc17a9
Name

solute carrier family 17, member 9
Synonyms

1700019H03Rik, MGC:28538, Vnut

Feature Type

protein coding gene
IDs

MGI:1919107
NCBI Gene: 228993
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:180367056-180384073 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 103.28 cM, cytoband H4
Mapping Data

3 experiments

SNPs within 2kb

395 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919107	protein coding gene	Chr2:180363989-180384073 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027002	protein coding gene	Chr2:187263336-187286751 (+)
A/J	MGP_AJ_G0026968	protein coding gene	Chr2:179569990-179589356 (+)
AKR/J	MGP_AKRJ_G0026938	protein coding gene	Chr2:184954722-184973827 (+)
BALB/cJ	MGP_BALBcJ_G0026977	protein coding gene	Chr2:180032295-180049918 (+)
C3H/HeJ	MGP_C3HHeJ_G0026718	protein coding gene	Chr2:185302502-185322936 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027423	protein coding gene	Chr2:192669116-192690207 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024788	protein coding gene	Chr2:170261621-170277745 (+)
CAST/EiJ	MGP_CASTEiJ_G0026177	protein coding gene	Chr2:183548254-183564944 (+)
CBA/J	MGP_CBAJ_G0026695	protein coding gene	Chr2:199675667-199695490 (+)
DBA/2J	MGP_DBA2J_G0026833	protein coding gene	Chr2:178665847-178684656 (+)
FVB/NJ	MGP_FVBNJ_G0026799	protein coding gene	Chr2:177281558-177301421 (+)
LP/J	MGP_LPJ_G0026934	protein coding gene	Chr2:187272959-187295993 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026818	protein coding gene	Chr2:202265863-202285728 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027482	protein coding gene	Chr2:184912166-184929849 (+)
PWK/PhJ	MGP_PWKPhJ_G0025913	protein coding gene	Chr2:176179591-176197526 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025713	protein coding gene	Chr2:181408686-181430685 (+)
WSB/EiJ	MGP_WSBEiJ_G0026249	protein coding gene	Chr2:185893222-185914671 (+)

Human Ortholog

SLC17A9, solute carrier family 17 member 9

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC17A9, solute carrier family 17 member 9
Synonyms

C20orf59, POROK8, VNUT
Links

HGNC:16192

NCBI Gene ID: 63910

neXtProt AC: NX_Q9BYT1

UniProt: Q9BYT1
Chr Location

20q13.33; chr20:62952707-62969585 (+) GRCh38

MGI Vertebrate Homology

Slc17a9 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC17A9
Gene Tree

Slc17a9

Diseases

1 with human SLC17A9 associations

				Human Disease	Mouse Models
				porokeratosis IDs porokeratosis DOID:3805 DOID:8668 ICD10CM:L56.5 ICD9CM:692.75 MESH:D017499 NCI:C85019 OMIM:175800 UMLS_CUI:C0162839 UMLS_CUI:C0265970

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 3 alleles in 3 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

57
Endonuclease-mediated

2
Gene trapped

49
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout affects the neuroendocrine system, resulting in hypoglycemia, increased glucose tolerance and increased insulin sensitivity.

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All GO Annotations

23
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

6
cDNA Data

33
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc17a9

ZFIN slc17a9b

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All Sequences

44
RefSeq

9
UniProt

2
CCDS

CCDS38378.1

Ensembl

ENSMUSG00000023393 (Evidence)
NCBI Gene

228993

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023393	Ensembl Gene Model \| MGI Sequence Detail	17018	C57BL/6J	± kb
transcript	ENSMUST00000094218	Ensembl \| MGI Sequence Detail	2275	Not Applicable
polypeptide	ENSMUSP00000091771	Ensembl \| MGI Sequence Detail	447	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014965 voltage-gated purine nucleotide uniporter SLC17A9

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR050382 Major Facilitator Superfamily Sodium/Anion Cotransporter

IPR036259 MFS transporter superfamily

IPR044777 Solute carrier family 17 member 9-like

IPR005829 Sugar transporter, conserved site

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All nucleic 33

cDNA 33

Microarray probesets 3

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MGI:2670971

Summaries

All 56

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 21
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc17a9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22267	Chr2:180367123-180367176 (+)	94 bp
Tssr22268	Chr2:180374021-180374064 (+)	6,987 bp
Tssr22269	Chr2:180374068-180374079 (+)	7,018 bp
Tssr22270	Chr2:180374083-180374090 (+)	7,031 bp
Tssr22271	Chr2:180379990-180380016 (+)	12,947 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24