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Fgg Gene Detail
Summary
  • Symbol
    Fgg
  • Name
    fibrinogen gamma chain
  • Synonyms
    3010002H13Rik, gamma-fibrinogen
  • Feature Type
    protein coding gene
  • IDs
    MGI:95526
    NCBI Gene: 99571
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:82915031-82922356 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 36.94 cM
  • Mapping Data
    29 experiments
Strain
Comparison
more
  • SNPs within 2kb
    290 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95526
 protein coding gene Chr3:82915031-82922363 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027331
 protein coding gene Chr3:82828606-82835893 (+)
A/J MGP_AJ_G0027295
 protein coding gene Chr3:80101380-80108652 (+)
AKR/J MGP_AKRJ_G0027261
 protein coding gene Chr3:82006996-82014278 (+)
BALB/cJ MGP_BALBcJ_G0027304
 protein coding gene Chr3:80192923-80200143 (+)
C3H/HeJ MGP_C3HHeJ_G0027048
 protein coding gene Chr3:82293142-82300414 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027750
 protein coding gene Chr3:85948176-85956659 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025103
 protein coding gene Chr3:75821486-75828877 (+)
CAST/EiJ MGP_CASTEiJ_G0026495
 protein coding gene Chr3:82477609-82484893 (+)
CBA/J MGP_CBAJ_G0027023
 protein coding gene Chr3:88855871-88862982 (+)
DBA/2J MGP_DBA2J_G0027159
 protein coding gene Chr3:79643621-79651480 (+)
FVB/NJ MGP_FVBNJ_G0027127
 protein coding gene Chr3:77925997-77933266 (+)
LP/J MGP_LPJ_G0027267
 protein coding gene Chr3:83816063-83824250 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027146
 protein coding gene Chr3:95245763-95254073 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027808
 protein coding gene Chr3:81801755-81809029 (+)
PWK/PhJ MGP_PWKPhJ_G0026229
 protein coding gene Chr3:79404813-79412329 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026045
 protein coding gene Chr3:80991989-80999258 (+)
WSB/EiJ MGP_WSBEiJ_G0026573
 protein coding gene Chr3:82136383-82144387 (+)



Homology
more
  • Human Ortholog
    FGG, fibrinogen gamma chain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGG, fibrinogen gamma chain
  • Links
    NCBI Gene ID: 2266
    neXtProt AC: NX_P02679
    UniProt: P02679

  • Chr Location
    4q32.1; chr4:154604134-154612967 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fgg mouse models; 3 with human FGG associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Pregnant homozygous null mice exhibit retarded embryo-placental development, spontaneous abortion, and maternal death through excessive uterine bleeding. Mutants expressing a truncated polypeptide show reduced platelet aggregation, increased bleeding time, and occasional fatal neonatal bleeding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    847
  • Tissues
    53
  • cDNA Data
    10
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033860 Ensembl Gene Model | MGI Sequence Detail 7326 C57BL/6J ±  kb
    transcript ENSMUST00000194175 Ensembl | MGI Sequence Detail 1741 Not Applicable  
    polypeptide ENSMUSP00000141648 Ensembl | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007507 fibrinogen gamma chain
      (term hierarchy)
    • InterPro Domains
      IPR037579 Fibrinogen
      IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR020837 Fibrinogen, conserved site
      IPR036056 Fibrinogen-like, C-terminal
    • GlyGen
      Q8VCM7 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9786, MGI:1924212, MGI:2139652
    References
    more
    • Summaries
      All 129
      Developmental Gene Expression 17
      Diseases 2
      Gene Ontology 9
      Phenotypes 54
    • Earliest
      J:9073 Blatt C, et al., Mapping and gene order of U1 small nuclear RNA, endogenous viral env sequence, amylase, and alcohol dehydrogenase-3 on mouse chromosome 3. Somat Cell Mol Genet. 1988 Mar;14(2):133-42
    • Latest
      J:337758 Mendiola AS, et al., Defining blood-induced microglia functions in neurodegeneration through multiomic profiling. Nat Immunol. 2023 Jul;24(7):1173-1187
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory