Acsf2 MGI Mouse Gene Detail - MGI:2388287 - acyl-CoA synthetase family member 2

Symbol

Acsf2
Name

acyl-CoA synthetase family member 2
Synonyms

MGC:25878

Feature Type

protein coding gene
IDs

MGI:2388287
NCBI Gene: 264895
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:94447928-94492697 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 58.90 cM
Mapping Data

1 experiment

SNPs within 2kb

1393 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2388287	protein coding gene	Chr11:94447928-94492822 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018961	protein coding gene	Chr11:96662918-96717592 (-)
A/J	MGP_AJ_G0018929	protein coding gene	Chr11:92789786-92836926 (-)
AKR/J	MGP_AKRJ_G0018899	protein coding gene	Chr11:95673881-95728515 (-)
BALB/cJ	MGP_BALBcJ_G0018902	protein coding gene	Chr11:93239963-93287661 (-)
C3H/HeJ	MGP_C3HHeJ_G0018716	protein coding gene	Chr11:95759145-95808946 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019354	protein coding gene	Chr11:99668859-99724021 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016985	protein coding gene	Chr11:90284672-90327203 (-)
CAST/EiJ	MGP_CASTEiJ_G0018271	protein coding gene	Chr11:96478624-96529998 (-)
CBA/J	MGP_CBAJ_G0018687	protein coding gene	Chr11:103800674-103872947 (-)
DBA/2J	MGP_DBA2J_G0018795	protein coding gene	Chr11:92366988-92414382 (-)
FVB/NJ	MGP_FVBNJ_G0018784	protein coding gene	Chr11:91787035-91835519 (-)
LP/J	MGP_LPJ_G0018865	protein coding gene	Chr11:97204935-97255467 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018811	protein coding gene	Chr11:103828239-103879301 (-)
NZO/HlLtJ	no annotation
PWK/PhJ	MGP_PWKPhJ_G0018041	protein coding gene	Chr11:93301888-93353031 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017831	protein coding gene	Chr11:95568259-95628504 (-)
WSB/EiJ	MGP_WSBEiJ_G0018320	protein coding gene	Chr11:95789713-95837500 (-)

Human Ortholog

ACSF2, acyl-CoA synthetase family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACSF2, acyl-CoA synthetase family member 2
Synonyms

ACSMW, AVYV493
Links

HGNC:26101

NCBI Gene ID: 80221

neXtProt AC: NX_Q96CM8

UniProt: Q96CM8
Chr Location

17q21.33; chr17:50426158-50474845 (+) GRCh38

MGI Vertebrate Homology

Acsf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACSF2
Gene Tree

Acsf2

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Gene trapped

4
Targeted

8
Genomic Mutations

4 involving Acsf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available

Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested.

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

740
Tissues

26
cDNA Data

26
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ACSF2

Xenbase acsf2

ZFIN acsf2

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All Sequences

37
RefSeq

3
UniProt

1
CCDS

CCDS25259.1

Ensembl

ENSMUSG00000076435 (Evidence)
NCBI Gene

264895

			Length	Strain/Species	Flank
genomic	ENSMUSG00000076435	Ensembl Gene Model \| MGI Sequence Detail	44770	C57BL/6J	± kb
transcript	ENSMUST00000103164	Ensembl \| MGI Sequence Detail	3154	Not Applicable
polypeptide	ENSMUSP00000099453	Ensembl \| MGI Sequence Detail	615	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003657 medium-chain acyl-CoA ligase ACSF2, mitochondrial

(term hierarchy)
EC

6.2.1.2
InterPro Domains

IPR020845 AMP-binding, conserved site

IPR025110 AMP-binding enzyme, C-terminal domain

IPR045851 AMP-binding enzyme, C-terminal domain superfamily

IPR000873 AMP-dependent synthetase/ligase domain

IPR042099 ANL, N-terminal domain
GlyGen

Q8VCW8 1 site, 1 O-linked glycan (1 site)

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All nucleic 27

Genomic 1

cDNA 26

Microarray probesets 3

Summaries

All 41

Developmental Gene Expression 1

Diseases 1

Gene Ontology 5

Phenotypes 18
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acsf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110206	Chr11:94492791-94492809 (-)	-103 bp
Tssr110205	Chr11:94492709-94492721 (-)	-18 bp
Tssr110204	Chr11:94492688-94492699 (-)	3 bp
Tssr110203	Chr11:94492651-94492677 (-)	33 bp
Tssr110202	Chr11:94492622-94492648 (-)	62 bp
Tssr110201	Chr11:94461367-94461377 (-)	31,325 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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