Sgip1 MGI Mouse Gene Detail - MGI:1920344 - SH3-domain GRB2-like (endophilin) interacting protein 1

Symbol

Sgip1
Name

SH3-domain GRB2-like (endophilin) interacting protein 1
Synonyms

3110007P09Rik

Feature Type

protein coding gene
IDs

MGI:1920344
NCBI Gene: 73094
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr4:102616351-102834623 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 47.09 cM
Mapping Data

1 experiment

SNPs within 2kb

6223 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920344	protein coding gene	Chr4:102598494-102834623 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028501	protein coding gene	Chr4:103141265-103370832 (+)
A/J	MGP_AJ_G0028464	protein coding gene	Chr4:99543867-99774424 (+)
AKR/J	MGP_AKRJ_G0028411	protein coding gene	Chr4:101953925-102189750 (+)
BALB/cJ	MGP_BALBcJ_G0028483	protein coding gene	Chr4:99739964-99968360 (+)
C3H/HeJ	MGP_C3HHeJ_G0028197	protein coding gene	Chr4:102742455-102981466 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028923	protein coding gene	Chr4:107030152-107265955 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026214	protein coding gene	Chr4:94905681-95117035 (+)
CAST/EiJ	MGP_CASTEiJ_G0027633	protein coding gene	Chr4:100497414-100736743 (+)
CBA/J	MGP_CBAJ_G0028166	protein coding gene	Chr4:110416194-110670499 (+)
DBA/2J	MGP_DBA2J_G0028314	protein coding gene	Chr4:99200841-99425621 (+)
FVB/NJ	MGP_FVBNJ_G0028281	protein coding gene	Chr4:98052213-98281798 (+)
LP/J	MGP_LPJ_G0028415	protein coding gene	Chr4:103451708-103671128 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028308	protein coding gene	Chr4:115892418-116132490 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028958	protein coding gene	Chr4:102161951-102409108 (+)
PWK/PhJ	MGP_PWKPhJ_G0027359	protein coding gene	Chr4:97407965-97633465 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027183	protein coding gene	Chr4:99594123-99822561 (+)
WSB/EiJ	MGP_WSBEiJ_G0027713	protein coding gene	Chr4:102346052-102574905 (+)

Human Ortholog

SGIP1, SH3GL interacting endocytic adaptor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SGIP1, SH3GL interacting endocytic adaptor 1
Links

HGNC:25412

NCBI Gene ID: 84251

neXtProt AC: NX_Q9BQI5

UniProt: Q9BQI5
Chr Location

1p31.3; chr1:66533267-66751139 (+) GRCh38

MGI Vertebrate Homology

Sgip1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SGIP1
Gene Tree

Sgip1

less

Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Targeted

4
Genomic Mutations

4 involving Sgip1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

37
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

56
cDNA Data

19
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sgip1

less

All Sequences

141
RefSeq

68
UniProt

5
CCDS

CCDS18404.1, CCDS71429.1, CCDS71430.1

Ensembl

ENSMUSG00000028524 (Evidence)
NCBI Gene

73094

			Length	Strain/Species	Flank
genomic	73094	NCBI Gene Model \| MGI Sequence Detail	218273	C57BL/6J	± kb
transcript	NM_001285852	RefSeq \| MGI Sequence Detail	5589	C57BL/6
polypeptide	Q8VD37	UniProt \| EBI \| MGI Sequence Detail	806	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000014788 SH3-containing GRB2-like protein 3-interacting protein 1

(term hierarchy)
EC

2.7.7.49
InterPro Domains

IPR036168 AP-2 complex subunit mu, C-terminal superfamily

IPR001584 Integrase, catalytic core

IPR036862 Integrase, C-terminal domain superfamily, retroviral

IPR001037 Integrase, C-terminal, retroviral

IPR017856 Integrase-like, N-terminal

IPR003308 Integrase, N-terminal zinc-binding domain

IPR028565 Mu homology domain

IPR018808 Muniscin, C-terminal

IPR012337 Ribonuclease H-like superfamily

IPR036397 Ribonuclease H superfamily

IPR037984 SGIP1, mu-homology domain
GlyGen

Q8VD37 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

less

All nucleic 21

cDNA 19

Primer pair 2

Microarray probesets 6

Summaries

All 48

Developmental Gene Expression 7

Gene Ontology 9

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sgip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38069	Chr4:102617361-102617381 (+)	1,020 bp
Tssr38070	Chr4:102617468-102617475 (+)	1,121 bp
Tssr38071	Chr4:102617491-102617572 (+)	1,181 bp
Tssr38072	Chr4:102682645-102682648 (+)	66,296 bp
Tssr38073	Chr4:102690874-102690876 (+)	74,524 bp
Tssr1245	Chr4:102813008-102813015 (+)	196,661 bp
Tssr38074	Chr4:102826270-102826273 (+)	209,921 bp
Tssr1246	Chr4:102833321-102833351 (+)	216,985 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24