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Washc1 Gene Detail
Summary
  • Symbol
    Washc1
  • Name
    WASH complex subunit 1
  • Synonyms
    1110049F14Rik, ORF19, Wash, Wash1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916017
    NCBI Gene: 68767
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:66418540-66427498 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 35.26 cM, cytoband F3-F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    411 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916017
 protein coding gene Chr17:66418524-66427498 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023985
 protein coding gene Chr17:68294187-68303751 (+)
A/J MGP_AJ_G0023943
 protein coding gene Chr17:66241087-66250065 (+)
AKR/J MGP_AKRJ_G0023912
 protein coding gene Chr17:67163989-67172925 (+)
BALB/cJ MGP_BALBcJ_G0023944
 protein coding gene Chr17:66189933-66198907 (+)
C3H/HeJ MGP_C3HHeJ_G0023708
 protein coding gene Chr17:68057032-68065959 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024390
 protein coding gene Chr17:70911967-70920924 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021836
 protein coding gene Chr17:62261547-62270858 (+)
CAST/EiJ MGP_CASTEiJ_G0023190
 protein coding gene Chr17:68408703-68417774 (+)
CBA/J MGP_CBAJ_G0023684
 protein coding gene Chr17:73701406-73711095 (+)
DBA/2J MGP_DBA2J_G0023812
 protein coding gene Chr17:64985105-64994061 (+)
FVB/NJ MGP_FVBNJ_G0023778
 protein coding gene Chr17:64471846-64482168 (+)
LP/J MGP_LPJ_G0023894
 protein coding gene Chr17:69000339-69009343 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023806
 protein coding gene Chr17:73789079-73799162 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024434
 protein coding gene Chr17:67620848-67630516 (+)
PWK/PhJ MGP_PWKPhJ_G0022936
 protein coding gene Chr17:64264618-64274007 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022747
 protein coding gene Chr17:64310910-64320007 (+)
WSB/EiJ MGP_WSBEiJ_G0023256
 protein coding gene Chr17:68323447-68334589 (+)



Homology
more
  • Human Ortholog
    WASH2P, WASP family homolog 2, pseudogene
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WASH2P, WASP family homolog 2, pseudogene
  • Synonyms
    FAM39B
  • Links
    NCBI Gene ID: 375260

  • Chr Location
    2q14.1; chr2:113583593-113599081 (+)  GRCh38
  • Human Ortholog
    WASH3P, WASP family homolog 3, pseudogene
  • Synonyms
    FAM39DP
  • Links
    NCBI Gene ID: 374666
    UniProt: C4AMC7

  • Chr Location
    15q26.3; chr15:101960813-101976605 (+)  GRCh38
  • Human Ortholog
    WASH4P, WASP family homolog 4, pseudogene
  • Synonyms
    CXYorf1P, FAM39CP
  • Links
    NCBI Gene ID: 374677

  • Chr Location
    16p13.3; chr16:14081-18091 (-)  GRCh38
  • Human Ortholog
    WASH6P, WASP family homolog 6, pseudogene
  • Synonyms
    CXYorf1, FAM39A, WASH
  • Links
    NCBI Gene ID: 653440
    UniProt: Q9NQA3

  • Chr Location
    XYq28 and Yq12
  • Human Ortholog
    WASHC1, WASH complex subunit 1
  • Synonyms
    FAM39E, WASH, WASH1
  • Links
    NCBI Gene ID: 100287171
    neXtProt AC: NX_A8K0Z3
    UniProt: A8K0Z3

  • Chr Location
    chr9:14475-73865 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality prior to E7.5 with increased cell death and autophagy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    19
  • cDNA Data
    44
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024101 Ensembl Gene Model | MGI Sequence Detail 8959 C57BL/6J ±  kb
    transcript ENSMUST00000072383 Ensembl | MGI Sequence Detail 2905 Not Applicable  
    polypeptide ENSMUSP00000072220 Ensembl | MGI Sequence Detail 475 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 1
      cDNA 44

      Microarray probesets 4
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 3
      Gene Ontology 16
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:343871 Heida A, et al., Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Dec 11;1869(2):159445
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory