About   Help   FAQ
Ccdc92 Gene Detail
Summary
  • Symbol
    Ccdc92
  • Name
    coiled-coil domain containing 92
  • Synonyms
    D5Bwg0834e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106485
    NCBI Gene: 215707
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:124911482-124939261 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.85 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    580 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106485
 protein coding gene Chr5:124911482-124939488 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030105
 protein coding gene Chr5:128618376-128648286 (-)
A/J MGP_AJ_G0030070
 protein coding gene Chr5:123256106-123285033 (-)
AKR/J MGP_AKRJ_G0030006
 protein coding gene Chr5:127240194-127269379 (-)
BALB/cJ MGP_BALBcJ_G0030081
 protein coding gene Chr5:124590105-124618134 (-)
C3H/HeJ MGP_C3HHeJ_G0029798
 protein coding gene Chr5:127838865-127866835 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030534
 protein coding gene Chr5:133619280-133647180 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027760
 protein coding gene Chr5:117789210-117815928 (-)
CAST/EiJ MGP_CASTEiJ_G0029207
 protein coding gene Chr5:126964570-126996630 (-)
CBA/J MGP_CBAJ_G0029768
 protein coding gene Chr5:138836056-138865649 (-)
DBA/2J MGP_DBA2J_G0029918
 protein coding gene Chr5:123273344-123301298 (-)
FVB/NJ MGP_FVBNJ_G0029874
 protein coding gene Chr5:122319960-122348528 (-)
LP/J MGP_LPJ_G0030007
 protein coding gene Chr5:129148162-129175936 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029905
 protein coding gene Chr5:142389953-142418656 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030575
 protein coding gene Chr5:126853585-126881390 (-)
PWK/PhJ MGP_PWKPhJ_G0028921
 protein coding gene Chr5:122105702-122133993 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028758
 protein coding gene Chr5:124487808-124515775 (-)
WSB/EiJ MGP_WSBEiJ_G0029281
 protein coding gene Chr5:127544448-127573074 (-)



Homology
more
  • Human Ortholog
    CCDC92, coiled-coil domain containing 92
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCDC92, coiled-coil domain containing 92
  • Links
    NCBI Gene ID: 80212
    neXtProt AC: NX_Q53HC0
    UniProt: Q53HC0

  • Chr Location
    12q24.31; chr12:123918660-123972831 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 2 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Under high-fat diet conditions, mice homozygous for a knock-out allele show decreased obesity, increased insulin sensitivity and glucose tolerance, reduced adipocyte differentiation and macrophage infiltration and fibrosis in white adipose tissue, increased energy expenditure, and decreased hepatic steatosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    845
  • Tissues
    42
  • cDNA Data
    5
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 215707 NCBI Gene Model | MGI Sequence Detail 27780 C57BL/6J ±  kb
    transcript NR_184680 RefSeq | MGI Sequence Detail 2333 ZRU/MplStud  
    polypeptide Q8VDN4 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 5
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-34179, MGI:2141141
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory