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Pdcd10 Gene Detail
Summary
  • Symbol
    Pdcd10
  • Name
    programmed cell death 10
  • Synonyms
    2410003B13Rik, CCM3, TF-1 cell apoptosis related protein-15, Tfa15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928396
    NCBI Gene: 56426
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:75423797-75464159 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 33.76 cM, cytoband E3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    905 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928396
 protein coding gene Chr3:75423797-75464163 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027306
 protein coding gene Chr3:74987603-75028891 (-)
A/J MGP_AJ_G0027268
 protein coding gene Chr3:72661858-72703278 (-)
AKR/J MGP_AKRJ_G0027236
 protein coding gene Chr3:74307572-74348251 (-)
BALB/cJ MGP_BALBcJ_G0027279
 protein coding gene Chr3:72649440-72689164 (-)
C3H/HeJ MGP_C3HHeJ_G0027023
 protein coding gene Chr3:74630991-74672208 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027725
 protein coding gene Chr3:77948730-77991488 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025078
 protein coding gene Chr3:68480842-68526453 (-)
CAST/EiJ MGP_CASTEiJ_G0026470
 protein coding gene Chr3:74570823-74621696 (-)
CBA/J MGP_CBAJ_G0026998
 protein coding gene Chr3:80433837-80478456 (-)
DBA/2J MGP_DBA2J_G0027134
 protein coding gene Chr3:72213805-72254006 (-)
FVB/NJ MGP_FVBNJ_G0027102
 protein coding gene Chr3:70600258-70639593 (-)
LP/J MGP_LPJ_G0027242
 protein coding gene Chr3:75993299-76033895 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027121
 protein coding gene Chr3:86256748-86300965 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027783
 protein coding gene Chr3:74127805-74168248 (-)
PWK/PhJ MGP_PWKPhJ_G0026204
 protein coding gene Chr3:71934620-71977174 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026020
 protein coding gene Chr3:73213010-73255364 (-)
WSB/EiJ MGP_WSBEiJ_G0026548
 protein coding gene Chr3:74397653-74442038 (-)



Homology
more
  • Human Ortholog
    PDCD10, programmed cell death 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDCD10, programmed cell death 10
  • Synonyms
    CCM3, TFAR15
  • Links
    NCBI Gene ID: 11235
    neXtProt AC: NX_Q9BUL8
    UniProt: Q9BUL8

  • Chr Location
    3q26.1; chr3:167683298-167734939 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pdcd10 mouse models; 1 with human PDCD10 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 5 alleles in 11 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout is embryonic lethal due to impaired hematopoeisis, vasculogenesis, and abnormal heart morphology. Conditional knockout in myeloids increases degranulation of, and exocytosis by, neutrophils.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    839
  • Tissues
    93
  • cDNA Data
    18
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56426 NCBI Gene Model | MGI Sequence Detail 40363 C57BL/6J ±  kb
    transcript NM_019745 RefSeq | MGI Sequence Detail 1923 C57BL/6  
    polypeptide Q8VE70 UniProt | EBI | MGI Sequence Detail 212 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000012451 programmed cell death protein 10
      (term hierarchy)
    • InterPro Domains
      IPR053750 Programmed Cell Death 10 Homolog
      IPR009652 Programmed cell death protein 10
      IPR048288 Programmed cell death protein 10, dimerisation domain
      IPR046409 Programmed cell death protein 10, dimerisation domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1913767
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 5
      Diseases 3
      Gene Ontology 10
      Phenotypes 39
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:339950 Phillips CM, et al., 20 kDa isoform of connexin-43 augments spatial reorganization of the brain endothelial junctional complex and lesion leakage in cerebral cavernous malformation type-3. Neurobiol Dis. 2023 Aug 29;186:106277
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory