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Cnot6l Gene Detail
Summary
  • Symbol
    Cnot6l
  • Name
    CCR4-NOT transcription complex, subunit 6-like
  • Synonyms
    4932442K20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443154
    NCBI Gene: 231464
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:96218192-96312030 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 47.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1378 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443154
 protein coding gene Chr5:96218192-96312044 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029763
 protein coding gene Chr5:97291188-97382980 (-)
A/J MGP_AJ_G0029729
 protein coding gene Chr5:93725200-93826273 (-)
AKR/J MGP_AKRJ_G0029675
 protein coding gene Chr5:96864168-96952831 (-)
BALB/cJ MGP_BALBcJ_G0029739
 protein coding gene Chr5:94726549-94808504 (-)
C3H/HeJ MGP_C3HHeJ_G0029462
 protein coding gene Chr5:97189523-97277575 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030194
 protein coding gene Chr5:101450035-101544367 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027429
 protein coding gene Chr5:89137435-89224812 (-)
CAST/EiJ MGP_CASTEiJ_G0028872
 protein coding gene Chr5:95775129-95862847 (-)
CBA/J MGP_CBAJ_G0029432
 protein coding gene Chr5:104960492-105059443 (-)
DBA/2J MGP_DBA2J_G0029576
 protein coding gene Chr5:93939945-94024644 (-)
FVB/NJ MGP_FVBNJ_G0029535
 protein coding gene Chr5:92772850-92854582 (-)
LP/J MGP_LPJ_G0029664
 protein coding gene Chr5:97955725-98054466 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029564
 protein coding gene Chr5:110013993-110153673 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030227
 protein coding gene Chr5:96290126-96381435 (-)
PWK/PhJ MGP_PWKPhJ_G0028591
 protein coding gene Chr5:92344332-92431364 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028426
 protein coding gene Chr5:93952371-94037557 (-)
WSB/EiJ MGP_WSBEiJ_G0028951
 protein coding gene Chr5:96610419-96697501 (-)



Homology
more
  • Human Ortholog
    CNOT6L, CCR4-NOT transcription complex subunit 6 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNOT6L, CCR4-NOT transcription complex subunit 6 like
  • Synonyms
    CCR4b
  • Links
    NCBI Gene ID: 246175
    neXtProt AC: NX_Q96LI5
    UniProt: Q96LI5

  • Chr Location
    4q21.1; chr4:77713387-77820269 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit protection from diet-induced obesity and metabolic disruptions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    59
  • cDNA Data
    17
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034724 Ensembl Gene Model | MGI Sequence Detail 93839 C57BL/6J ±  kb
    transcript ENSMUST00000113005 Ensembl | MGI Sequence Detail 3170 Not Applicable  
    polypeptide ENSMUSP00000108629 Ensembl | MGI Sequence Detail 555 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000005654 CCR4-NOT transcription complex subunit 6-like
      (term hierarchy)
    • EC
      3.1.13.4
    • InterPro Domains
      IPR050410 CCR4/nocturin mRNA turnover and transcription
      IPR034967 CCR4-NOT transcription complex subunit 6-like
      IPR005135 Endonuclease/exonuclease/phosphatase
      IPR036691 Endonuclease/exonuclease/phosphatase superfamily
      IPR001611 Leucine-rich repeat
      IPR025875 Leucine rich repeat 4
      IPR050715 Leucine-rich repeat and signaling effector domain-containing protein
      IPR050216 Leucine-rich repeat domain-containing protein
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 11
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 12
      Gene Ontology 8
      Phenotypes 23
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:336923 Jiang X, et al., Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice. Nat Commun. 2023 Jun 22;14(1):3729
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory