Slc25a3 MGI Mouse Gene Detail - MGI:1353498 - solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3

Symbol

Slc25a3
Name

solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
Synonyms

5730556H19Rik, Phc

Feature Type

protein coding gene
IDs

MGI:1353498
NCBI Gene: 18674
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:90952436-90959902 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 45.60 cM
Mapping Data

2 experiments

SNPs within 2kb

279 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1353498	protein coding gene	Chr10:90952436-90959921 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017644	protein coding gene	Chr10:92405151-92413144 (-)
A/J	MGP_AJ_G0017623	protein coding gene	Chr10:89200650-89208728 (-)
AKR/J	MGP_AKRJ_G0017581	protein coding gene	Chr10:91762892-91770377 (-)
BALB/cJ	MGP_BALBcJ_G0017586	protein coding gene	Chr10:89483465-89490950 (-)
C3H/HeJ	MGP_C3HHeJ_G0017409	protein coding gene	Chr10:91781309-91788794 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018043	protein coding gene	Chr10:95462443-95469928 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015725	protein coding gene	Chr10:84870110-84877644 (-)
CAST/EiJ	MGP_CASTEiJ_G0016974	protein coding gene	Chr10:91707073-91715352 (-)
CBA/J	MGP_CBAJ_G0017378	protein coding gene	Chr10:99405051-99418640 (-)
DBA/2J	MGP_DBA2J_G0017484	protein coding gene	Chr10:88323823-88332911 (-)
FVB/NJ	MGP_FVBNJ_G0017476	protein coding gene	Chr10:87544636-87552424 (-)
LP/J	MGP_LPJ_G0017558	protein coding gene	Chr10:93039262-93046747 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017507	protein coding gene	Chr10:100863970-100871476 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018080	protein coding gene	Chr10:91649492-91656977 (-)
PWK/PhJ	MGP_PWKPhJ_G0016755	protein coding gene	Chr10:88379428-88390000 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016543	protein coding gene	Chr10:90408282-90415741 (-)
WSB/EiJ	MGP_WSBEiJ_G0017033	protein coding gene	Chr10:91620284-91627773 (-)

Human Ortholog

SLC25A3, solute carrier family 25 member 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC25A3, solute carrier family 25 member 3
Synonyms

OK/SW-cl.48, PHC, PiC, PTP
Links

HGNC:10989

NCBI Gene ID: 5250

neXtProt AC: NX_Q00325

UniProt: Q00325
Chr Location

12q23.1; chr12:98593591-98606379 (+) GRCh38

MGI Vertebrate Homology

Slc25a3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC25A3
Gene Tree

Slc25a3

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

15
Targeted

4
Transgenic

3
Transposon induced

1
Genomic Mutations

3 involving Slc25a3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1143
Tissues

182
cDNA Data

697
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc25a3

ZFIN slc25a3a, slc25a3b

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All Sequences

105
RefSeq

7
UniProt

6
CCDS

CCDS24121.1

Ensembl

ENSMUSG00000061904 (Evidence)
NCBI Gene

18674

			Length	Strain/Species	Flank
genomic	18674	NCBI Gene Model \| MGI Sequence Detail	7467	C57BL/6J	± kb
transcript	NM_001428747	RefSeq \| MGI Sequence Detail	1428	C57BL/6
polypeptide	Q8VEM8	UniProt \| EBI \| MGI Sequence Detail	357	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000015026 solute carrier family 25 member 3

(term hierarchy)
InterPro Domains

IPR023395 Mitochondrial carrier domain superfamily

IPR044677 Mitochondrial phosphate carrier protein SLC25A3/Pic2/Mir1-like

IPR018108 Mitochondrial substrate/solute carrier
GlyGen

Q8VEM8 1 site, 1 O-linked glycan (1 site)

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All nucleic 705

cDNA 700

Primer pair 4

Other 1

Microarray probesets 4

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MGD-MRK-13291, MGI:1915351, MGI:97573

Summaries

All 66

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 23
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc25a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98909	Chr10:90959817-90959906 (-)	40 bp
Tssr98908	Chr10:90959124-90959177 (-)	751 bp
Tssr98907	Chr10:90958718-90958734 (-)	1,176 bp
Tssr98906	Chr10:90957808-90957856 (-)	2,070 bp
Tssr98905	Chr10:90954059-90954073 (-)	5,836 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24