Selenom MGI Mouse Gene Detail - MGI:2149786

Symbol

Selenom
Name

selenoprotein M
Synonyms

1500040L08Rik, Selm, SelM

Feature Type

protein coding gene
IDs

MGI:2149786
NCBI Gene: 114679
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:3464684-3467351 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 2.47 cM, cytoband A1
Mapping Data

3 experiments

SNPs within 2kb

109 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2149786	protein coding gene	Chr11:3464684-3467351 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017960	protein coding gene	Chr11:388905-391572 (+)
A/J	MGP_AJ_G0017933	protein coding gene	Chr11:432272-434939 (+)
AKR/J	MGP_AKRJ_G0017897	protein coding gene	Chr11:450159-452827 (+)
BALB/cJ	MGP_BALBcJ_G0017901	protein coding gene	Chr11:405231-407897 (+)
C3H/HeJ	MGP_C3HHeJ_G0017714	protein coding gene	Chr11:388522-391191 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018354	protein coding gene	Chr11:462903-465570 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016013	protein coding gene	Chr11:341545-344254 (+)
CAST/EiJ	MGP_CASTEiJ_G0017276	protein coding gene	Chr11:339440-343496 (+)
CBA/J	MGP_CBAJ_G0017689	protein coding gene	Chr11:625959-628627 (+)
DBA/2J	MGP_DBA2J_G0017800	protein coding gene	Chr11:350872-353540 (+)
FVB/NJ	MGP_FVBNJ_G0017791	protein coding gene	Chr11:382241-384908 (+)
LP/J	MGP_LPJ_G0017870	protein coding gene	Chr11:486684-489351 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017817	protein coding gene	Chr11:371833-374500 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018393	protein coding gene	Chr11:463421-466089 (+)
PWK/PhJ	MGP_PWKPhJ_G0017056	protein coding gene	Chr11:325991-328864 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016852	protein coding gene	Chr11:417154-419816 (+)
WSB/EiJ	MGP_WSBEiJ_G0017330	protein coding gene	Chr11:338897-341567 (+)

Human Ortholog

SELENOM, selenoprotein M

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SELENOM, selenoprotein M
Synonyms

SELM, SEPM
Links

HGNC:30397

NCBI Gene ID: 140606

neXtProt AC: NX_Q8WWX9

UniProt: Q8WWX9
Chr Location

22q12.2; chr22:31104772-31120069 (-) GRCh38

MGI Vertebrate Homology

Selenom stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SELENOM
Gene Tree

Selenom

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Gene trapped

5
Targeted

1
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit obesity without cognitive deficits.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

771
Tissues

13
cDNA Data

67
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase selenom

ZFIN selenom

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All Sequences

41
RefSeq

2
UniProt

1
CCDS

CCDS24365.1

Ensembl

ENSMUSG00000075702 (Evidence)
NCBI Gene

114679

			Length	Strain/Species	Flank
genomic	114679	NCBI Gene Model \| MGI Sequence Detail	2668	C57BL/6J	± kb
transcript	NM_053267	RefSeq \| MGI Sequence Detail	906	Not Specified
polypeptide	Q8VHC3	UniProt \| EBI \| MGI Sequence Detail	145	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014610 selenoprotein M

(term hierarchy)
PDB

2A2P
InterPro Domains

IPR039992 Selenoprotein F/M

IPR014912 Selenoprotein F/M domain

IPR038219 Selenoprotein F/M, thioredoxin-like domain superfamily

IPR036249 Thioredoxin-like superfamily

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All nucleic 69

cDNA 68

Other 1

Microarray probesets 2

Summaries

All 32

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:235561 Gladyshev VN, et al., Selenoprotein Gene Nomenclature. J Biol Chem. 2016 Nov 11;291(46):24036-24040

TSS for Selenom:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100056	Chr11:3464861-3464894 (+)	194 bp
Tssr100057	Chr11:3464897-3464928 (+)	229 bp
Tssr100058	Chr11:3464930-3464952 (+)	257 bp
Tssr3409	Chr11:3466055-3466073 (+)	1,380 bp
Tssr100059	Chr11:3466829-3466876 (+)	2,169 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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