Slc14a1 MGI Mouse Gene Detail - MGI:1351654 - solute carrier family 14 (urea transporter), member 1

Symbol

Slc14a1
Name

solute carrier family 14 (urea transporter), member 1
Synonyms

2610507K20Rik, 3021401A05Rik, UT-B

Feature Type

protein coding gene
IDs

MGI:1351654
NCBI Gene: 108052
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr18:78143306-78185334 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 52.49 cM
Mapping Data

3 experiments

SNPs within 2kb

1494 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351654	protein coding gene	Chr18:78143306-78185334 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024583	protein coding gene	Chr18:78905789-78948796 (-)
A/J	MGP_AJ_G0024550	protein coding gene	Chr18:75442267-75483579 (-)
AKR/J	MGP_AKRJ_G0024521	protein coding gene	Chr18:77670439-77712536 (-)
BALB/cJ	MGP_BALBcJ_G0024549	protein coding gene	Chr18:75635860-75677708 (-)
C3H/HeJ	MGP_C3HHeJ_G0024318	protein coding gene	Chr18:77773820-77816968 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024996	protein coding gene	Chr18:80961635-81004664 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022426	protein coding gene	Chr18:74394628-74436832 (-)
CAST/EiJ	MGP_CASTEiJ_G0023790	protein coding gene	Chr18:78104076-78145787 (-)
CBA/J	MGP_CBAJ_G0024287	protein coding gene	Chr18:83863042-83912546 (-)
DBA/2J	MGP_DBA2J_G0024417	protein coding gene	Chr18:74984731-75026977 (-)
FVB/NJ	MGP_FVBNJ_G0024383	protein coding gene	Chr18:74347693-74391347 (-)
LP/J	MGP_LPJ_G0024501	protein coding gene	Chr18:78790277-78836626 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024413	protein coding gene	Chr18:85072357-85117956 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025044	protein coding gene	Chr18:77850729-77894417 (-)
PWK/PhJ	MGP_PWKPhJ_G0023535	protein coding gene	Chr18:75420413-75463850 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023339	protein coding gene	Chr18:78029789-78077277 (-)
WSB/EiJ	MGP_WSBEiJ_G0023854	protein coding gene	Chr18:77797988-77842579 (-)

Human Ortholog

SLC14A1, solute carrier family 14 member 1 (Kidd blood group)

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC14A1, solute carrier family 14 member 1 (Kidd blood group)
Synonyms

HsT1341, HUT11, HUT11A, JK, Jk(a), Jk(b), RACH1, RACH2, UT1, UT-B1, UTE
Links

HGNC:10918

NCBI Gene ID: 6563

neXtProt AC: NX_Q13336

UniProt: Q13336
Chr Location

18q12.3; chr18:45687025-45752520 (+) GRCh38

MGI Vertebrate Homology

Slc14a1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC14A1
Protein SuperFamily

Urea_transporter
Gene Tree

Slc14a1

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Phenotype Summary

18 phenotypes from 1 allele in 2 genetic backgrounds
12 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

3
Targeted

1
Transposon induced

1
Genomic Mutations

1 involving Slc14a1
Incidental Mutations

CvDC
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display a grossly normal phenotype although they have an inability to concentrate urea in urine.

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All GO Annotations

19
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

998
Tissues

207
cDNA Data

39
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

51
RefSeq

6
UniProt

2
CCDS

CCDS29360.1, CCDS50330.1

Ensembl

ENSMUSG00000059336 (Evidence)
NCBI Gene

108052

			Length	Strain/Species	Flank
genomic	108052	NCBI Gene Model \| MGI Sequence Detail	42029	C57BL/6J	± kb
transcript	NM_001171010	RefSeq \| MGI Sequence Detail	3880	C57BL/6
polypeptide	Q8VHL0	UniProt \| EBI \| MGI Sequence Detail	384	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014938 urea transporter 1

(term hierarchy)
InterPro Domains

IPR029020 Ammonium/urea transporter

IPR004937 Urea transporter
GlyGen

Q8VHL0 1 site

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All nucleic 41

cDNA 39

Primer pair 2

Microarray probesets 5

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MGI:1917932, MGI:1919392

Summaries

All 52

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 15
Earliest

J:59121 Fenton RA, et al., The murine urea transporter genes Slc14a1 and Slc14a2 occur in tandem on chromosome 18. Cytogenet Cell Genet. 1999;87(1-2):95-6
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Slc14a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr153972	Chr18:78185382-78185391 (-)	-53 bp
Tssr153971	Chr18:78185352-78185369 (-)	-27 bp
Tssr153970	Chr18:78185294-78185305 (-)	34 bp
Tssr153969	Chr18:78166595-78166605 (-)	18,734 bp
Tssr5384	Chr18:78166584-78166587 (-)	18,748 bp
Tssr153968	Chr18:78166539-78166553 (-)	18,788 bp
Tssr153967	Chr18:78144691-78144702 (-)	40,637 bp
Tssr153966	Chr18:78144623-78144637 (-)	40,704 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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