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Acot11 Gene Detail
Summary
  • Symbol
    Acot11
  • Name
    acyl-CoA thioesterase 11
  • Synonyms
    1110020M10Rik, 2010309H15Rik, BFIT1, MGC:25974, mKIAA0707, Thea, Them1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913736
    NCBI Gene: 329910
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:106601752-106662195 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 49.75 cM, cytoband C7
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2050 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913736
 protein coding gene Chr4:106601752-106662204 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028527
 protein coding gene Chr4:107387845-107453069 (-)
A/J MGP_AJ_G0028490
 protein coding gene Chr4:103546880-103607507 (-)
AKR/J MGP_AKRJ_G0028437
 protein coding gene Chr4:106066235-106132174 (-)
BALB/cJ MGP_BALBcJ_G0028509
 protein coding gene Chr4:103737192-103797914 (-)
C3H/HeJ MGP_C3HHeJ_G0028223
 protein coding gene Chr4:106818031-106879464 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028949
 protein coding gene Chr4:111257575-111326301 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026240
 protein coding gene Chr4:98823903-98881449 (-)
CAST/EiJ MGP_CASTEiJ_G0027659
 protein coding gene Chr4:104624464-104692854 (-)
CBA/J MGP_CBAJ_G0028192
 protein coding gene Chr4:114850633-114931254 (-)
DBA/2J MGP_DBA2J_G0028340
 protein coding gene Chr4:103165569-103226755 (-)
FVB/NJ MGP_FVBNJ_G0028308
 protein coding gene Chr4:102025008-102087916 (-)
LP/J MGP_LPJ_G0028441
 protein coding gene Chr4:107587878-107654112 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028334
 protein coding gene Chr4:120175405-120242047 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028985
 protein coding gene Chr4:106315987-106379158 (-)
PWK/PhJ MGP_PWKPhJ_G0027385
 protein coding gene Chr4:101402452-101462598 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027209
 protein coding gene Chr4:103705210-103771997 (-)
WSB/EiJ MGP_WSBEiJ_G0027740
 protein coding gene Chr4:106490176-106555382 (-)



Homology
more
  • Human Ortholog
    ACOT11, acyl-CoA thioesterase 11
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACOT11, acyl-CoA thioesterase 11
  • Synonyms
    BFIT, STARD14, THEA, THEM1
  • Links
    NCBI Gene ID: 26027
    neXtProt AC: NX_Q8WXI4
    UniProt: Q8WXI4

  • Chr Location
    1p32.3; chr1:54542257-54639192 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display resistance to high fat diet induced obesity, inflammation and hepatic steatosis, increased energy expenditure, increased brown adipose tissue amount, and increased food intake.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034853 Ensembl Gene Model | MGI Sequence Detail 60444 C57BL/6J ±  kb
    transcript ENSMUST00000065253 Ensembl | MGI Sequence Detail 2939 Not Applicable  
    polypeptide ENSMUSP00000069636 Ensembl | MGI Sequence Detail 614 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915900, MGI:2140551
    References
    more
    • Summaries
      All 46
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:257468 Desai A, et al., Regulation of fatty acid trafficking in liver by thioesterase superfamily member 1. J Lipid Res. 2018 Feb;59(2):368-379
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory