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Oas3 Gene Detail
Summary
  • Symbol
    Oas3
  • Name
    2'-5' oligoadenylate synthetase 3
  • Synonyms
    2'-5' oligoadenylate synthetase-like 10, Oasl10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180850
    NCBI Gene: 246727
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:120891163-120915726 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 60.64 cM, cytoband f
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    654 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180850
 protein coding gene Chr5:120891163-120915755 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030014
 protein coding gene Chr5:124159977-124185661 (-)
A/J MGP_AJ_G0029978
 protein coding gene Chr5:119001855-119026413 (-)
AKR/J MGP_AKRJ_G0029917
 protein coding gene Chr5:122844430-122870245 (-)
BALB/cJ MGP_BALBcJ_G0029989
 protein coding gene Chr5:120418537-120443116 (-)
C3H/HeJ MGP_C3HHeJ_G0029709
 protein coding gene Chr5:123383676-123410332 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030444
 protein coding gene Chr5:128809970-128841359 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027670
 protein coding gene Chr5:113706675-113732205 (-)
CAST/EiJ MGP_CASTEiJ_G0029118
 protein coding gene Chr5:122512696-122538487 (-)
CBA/J MGP_CBAJ_G0029677
 protein coding gene Chr5:133818029-133849459 (-)
DBA/2J MGP_DBA2J_G0029827
 protein coding gene Chr5:119090150-119114617 (-)
FVB/NJ MGP_FVBNJ_G0029783
 protein coding gene Chr5:118021171-118047558 (-)
LP/J MGP_LPJ_G0029915
 protein coding gene Chr5:124607506-124635975 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029814
 protein coding gene Chr5:137761736-137786628 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030485
 protein coding gene Chr5:122420905-122447615 (-)
PWK/PhJ MGP_PWKPhJ_G0028831
 protein coding gene Chr5:117850846-117877945 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028670
 protein coding gene Chr5:120087968-120125739 (-)
WSB/EiJ MGP_WSBEiJ_G0029193
 protein coding gene Chr5:123015626-123040922 (-)



Homology
more
  • Human Ortholog
    OAS3, 2'-5'-oligoadenylate synthetase 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OAS3, 2'-5'-oligoadenylate synthetase 3
  • Synonyms
    p100, p100OAS
  • Links
    NCBI Gene ID: 4940
    neXtProt AC: NX_Q9Y6K5
    UniProt: Q9Y6K5

  • Chr Location
    12q24.13; chr12:112938051-112976460 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    15
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032661 Ensembl Gene Model | MGI Sequence Detail 24564 C57BL/6J ±  kb
transcript ENSMUST00000044833 Ensembl | MGI Sequence Detail 4720 Not Applicable  
polypeptide ENSMUSP00000035588 Ensembl | MGI Sequence Detail 1138 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000011576 2'-5'-oligoadenylate synthase 3
    (term hierarchy)
  • EC
    2.7.7.84
  • InterPro Domains
    IPR006116 2-5OAS/ClassI-CCAase, nucleotidyltransferase domain
    IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
    IPR006117 2-5-oligoadenylate synthetase, C-terminal conserved site
    IPR043518 2-5-oligoadenylate synthetase, N-terminal conserved site
    IPR043519 Nucleotidyltransferase superfamily
    IPR002934 Polymerase, nucleotidyl transferase domain
Molecular
Reagents
less
  • All nucleic 24
    Genomic 9
    cDNA 15

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory