Fitm1 MGI Mouse Gene Detail - MGI:1915930 - fat storage-inducing transmembrane protein 1

Symbol

Fitm1
Name

fat storage-inducing transmembrane protein 1
Synonyms

1110028A07Rik, Cg10671, Fit1

Feature Type

protein coding gene
IDs

MGI:1915930
NCBI Gene: 68680
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:55813131-55814409 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.19 cM
Mapping Data

3 experiments

SNPs within 2kb

85 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915930	protein coding gene	Chr14:55813074-55814411 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021350	protein coding gene	Chr14:49610760-49612095 (+)
A/J	MGP_AJ_G0021309	protein coding gene	Chr14:48622037-48623372 (+)
AKR/J	MGP_AKRJ_G0021285	protein coding gene	Chr14:50368116-50369451 (+)
BALB/cJ	MGP_BALBcJ_G0021313	protein coding gene	Chr14:48568415-48569750 (+)
C3H/HeJ	MGP_C3HHeJ_G0021093	protein coding gene	Chr14:50054718-50056053 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021751	protein coding gene	Chr14:52106327-52107662 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019298	protein coding gene	Chr14:46996759-46998098 (+)
CAST/EiJ	MGP_CASTEiJ_G0020612	protein coding gene	Chr14:46319281-46320619 (+)
CBA/J	MGP_CBAJ_G0021060	protein coding gene	Chr14:53660472-53661807 (+)
DBA/2J	MGP_DBA2J_G0021181	protein coding gene	Chr14:48348206-48349544 (+)
FVB/NJ	MGP_FVBNJ_G0021163	protein coding gene	Chr14:47796758-47798094 (+)
LP/J	MGP_LPJ_G0021255	protein coding gene	Chr14:50655164-50656499 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021187	protein coding gene	Chr14:53022259-53023595 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021778	protein coding gene	Chr14:49556909-49558244 (+)
PWK/PhJ	MGP_PWKPhJ_G0020359	protein coding gene	Chr14:44879506-44880841 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020187	protein coding gene	Chr14:45560497-45561823 (+)
WSB/EiJ	MGP_WSBEiJ_G0020665	protein coding gene	Chr14:49840541-49841874 (+)

Human Ortholog

FITM1, fat storage inducing transmembrane protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FITM1, fat storage inducing transmembrane protein 1
Synonyms

FIT1
Links

HGNC:33714

NCBI Gene ID: 161247

neXtProt AC: NX_A5D6W6

UniProt: A5D6W6
Chr Location

14q12; chr14:24130659-24132849 (+) GRCh38

MGI Vertebrate Homology

Fitm1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FITM1
Gene Tree

Fitm1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

3
Genomic Mutations

1 involving Fitm1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout increases survival after pressure overload-induced heart failure.

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

12
cDNA Data

31
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fitm1

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All Sequences

34
RefSeq

2
UniProt

1
CCDS

CCDS27116.1

Ensembl

ENSMUSG00000022215 (Evidence)
NCBI Gene

68680

			Length	Strain/Species	Flank
genomic	68680	NCBI Gene Model \| MGI Sequence Detail	1279	C57BL/6J	± kb
transcript	NM_026808	RefSeq \| MGI Sequence Detail	912	BFM2/Ms
polypeptide	Q91V79	UniProt \| EBI \| MGI Sequence Detail	292	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007528 fat storage-inducing transmembrane protein 1

(term hierarchy)
InterPro Domains

IPR019388 Fat storage-inducing transmembrane protein

IPR046402 Fat storage-inducing transmembrane protein 1

IPR046401 Fat storage-inducing transmembrane protein 1/2

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All nucleic 32

cDNA 31

Primer pair 1

Microarray probesets 3

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MGI:2145771

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:303195 Nishihama N, et al., Mice lacking fat storage-inducing transmembrane protein 2 show improved profiles upon pressure overload-induced heart failure. Heliyon. 2019 Mar;5(3):e01292

TSS for Fitm1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125773	Chr14:55812991-55813025 (+)	-123 bp
Tssr125774	Chr14:55813076-55813117 (+)	-34 bp
Tssr4431	Chr14:55813162-55813167 (+)	34 bp
Tssr125775	Chr14:55813172-55813258 (+)	84 bp
Tssr125776	Chr14:55813262-55813309 (+)	155 bp
Tssr125777	Chr14:55813312-55813323 (+)	187 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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