Lgals12 MGI Mouse Gene Detail - MGI:1929094 - lectin, galactose binding, soluble 12

Symbol

Lgals12
Name

lectin, galactose binding, soluble 12
Synonyms

galectin-12, galectin-related inhibitor of proliferation, GRIP1

Feature Type

protein coding gene
IDs

MGI:1929094
NCBI Gene: 56072
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:7574025-7584558 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 5.33 cM
Mapping Data

1 experiment

SNPs within 2kb

329 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929094	protein coding gene	Chr19:7574021-7584601 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024795	protein coding gene	Chr19:4747989-4758549 (-)
A/J	MGP_AJ_G0024762	protein coding gene	Chr19:4392392-4402922 (-)
AKR/J	MGP_AKRJ_G0024735	protein coding gene	Chr19:4513808-4524341 (-)
BALB/cJ	MGP_BALBcJ_G0024762	protein coding gene	Chr19:4492302-4502833 (-)
C3H/HeJ	MGP_C3HHeJ_G0024529	protein coding gene	Chr19:4650910-4661437 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025208	protein coding gene	Chr19:4847094-4857626 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022642	protein coding gene	Chr19:4288577-4299187 (-)
CAST/EiJ	MGP_CASTEiJ_G0024002	protein coding gene	Chr19:4562198-4572758 (-)
CBA/J	MGP_CBAJ_G0024502	protein coding gene	Chr19:4909003-4919540 (-)
DBA/2J	MGP_DBA2J_G0024629	protein coding gene	Chr19:4339483-4351030 (-)
FVB/NJ	MGP_FVBNJ_G0024594	protein coding gene	Chr19:4381953-4392450 (-)
LP/J	MGP_LPJ_G0024715	protein coding gene	Chr19:4593317-4603848 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024624	protein coding gene	Chr19:4813527-4824060 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025256	protein coding gene	Chr19:4683272-4693805 (-)
PWK/PhJ	MGP_PWKPhJ_G0023748	protein coding gene	Chr19:4404363-4415285 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023552	protein coding gene	Chr19:4477484-4488027 (-)
WSB/EiJ	MGP_WSBEiJ_G0024064	protein coding gene	Chr19:4573100-4583610 (-)

Human Ortholog

LGALS12, galectin 12

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LGALS12, galectin 12
Synonyms

GAL12, GRIP1
Links

HGNC:15788

NCBI Gene ID: 85329

neXtProt AC: NX_Q96DT0

UniProt: Q96DT0
Chr Location

11q12.3; chr11:63506052-63516774 (+) GRCh38

MGI Vertebrate Homology

Lgals12 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LGALS12
Gene Tree

Lgals12

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Phenotype Summary

21 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
1 images
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased lipolysis, reduced adiposity, and enhanced insulin sensitivity.

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

17

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lgals12

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All Sequences

46
RefSeq

8
UniProt

2
CCDS

CCDS29529.1, CCDS89332.1

Ensembl

ENSMUSG00000024972 (Evidence)
NCBI Gene

56072

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024972	Ensembl Gene Model \| MGI Sequence Detail	10534	C57BL/6J	± kb
transcript	ENSMUST00000099729	Ensembl \| MGI Sequence Detail	2757	Not Applicable
polypeptide	ENSMUSP00000097318	Ensembl \| MGI Sequence Detail	314	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009767 galectin-12

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR001079 Galectin, carbohydrate recognition domain

IPR044156 Galectin-like

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All nucleic 17

cDNA 17

Microarray probesets 3

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MGI:2147762

Summaries

All 27

Gene Ontology 2

Phenotypes 5
Earliest

J:74956 Hotta K, et al., Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing Apoptosis-inducing Activity. J Biol Chem. 2001 Sep 7;276(36):34089-97
Latest

J:354181 Lin FJ, et al., Galectin-12 Regulates Immune Responses in the Skin through Sebaceous Glands. J Invest Dermatol. 2023 May 18;

TSS for Lgals12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157997	Chr19:7584505-7584568 (-)	21 bp
Tssr157996	Chr19:7584319-7584330 (-)	233 bp
Tssr157995	Chr19:7575334-7575352 (-)	9,215 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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