Nifk MGI Mouse Gene Detail - MGI:1915199 - nucleolar protein interacting with the FHA domain of MKI67

Symbol

Nifk
Name

nucleolar protein interacting with the FHA domain of MKI67
Synonyms

C130020J04Rik, Mki67ip

Feature Type

protein coding gene
IDs

MGI:1915199
NCBI Gene: 67949
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:118249569-118261552 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 52.14 cM
Mapping Data

2 experiments

SNPs within 2kb

339 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915199	protein coding gene	Chr1:118249569-118261561 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016390	protein coding gene	Chr1:121000548-121012481 (+)
A/J	MGP_AJ_G0016373	protein coding gene	Chr1:116688825-116700742 (+)
AKR/J	MGP_AKRJ_G0016338	protein coding gene	Chr1:120130415-120143853 (+)
BALB/cJ	MGP_BALBcJ_G0016333	protein coding gene	Chr1:116943228-116957766 (+)
C3H/HeJ	MGP_C3HHeJ_G0016159	protein coding gene	Chr1:120302071-120313995 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016794	protein coding gene	Chr1:125622028-125633940 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014507	protein coding gene	Chr1:110372442-110384188 (+)
CAST/EiJ	MGP_CASTEiJ_G0015740	protein coding gene	Chr1:119025015-119037043 (+)
CBA/J	MGP_CBAJ_G0016132	protein coding gene	Chr1:129989243-130001201 (+)
DBA/2J	MGP_DBA2J_G0016238	protein coding gene	Chr1:115700473-115712583 (+)
FVB/NJ	MGP_FVBNJ_G0016237	protein coding gene	Chr1:114431900-114443816 (+)
LP/J	MGP_LPJ_G0016309	protein coding gene	Chr1:122351832-122364094 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016262	protein coding gene	Chr1:135784434-135796376 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016830	protein coding gene	Chr1:119819335-119831274 (+)
PWK/PhJ	MGP_PWKPhJ_G0015526	protein coding gene	Chr1:114668787-114680979 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015314	protein coding gene	Chr1:118707357-118719191 (+)
WSB/EiJ	MGP_WSBEiJ_G0015802	protein coding gene	Chr1:119717906-119729848 (+)

Human Ortholog

NIFK, nucleolar protein interacting with the FHA domain of MKI67

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NIFK, nucleolar protein interacting with the FHA domain of MKI67
Synonyms

MKI67IP, Nopp34
Links

HGNC:17838

NCBI Gene ID: 84365

neXtProt AC: NX_Q9BYG3

UniProt: Q9BYG3
Chr Location

2q14.3; chr2:121726945-121736911 (-) GRCh38

MGI Vertebrate Homology

Nifk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NIFK
Gene Tree

Nifk

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
1 images
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

3
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Nifk
Incidental Mutations

CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show complete embryonic lethality before implantation. In vitro, embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming outgrowths.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NIFK

Xenbase nifk

ZFIN nifk

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All Sequences

47
RefSeq

2
UniProt

3
CCDS

CCDS15222.1

Ensembl

ENSMUSG00000026377 (Evidence)
NCBI Gene

67949

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026377	Ensembl Gene Model \| MGI Sequence Detail	11984	C57BL/6J	± kb
transcript	ENSMUST00000027626	Ensembl \| MGI Sequence Detail	1889	Not Applicable
polypeptide	ENSMUSP00000027626	Ensembl \| MGI Sequence Detail	317	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029630 MKI67 FHA domain-interacting nucleolar phosphoprotein

(term hierarchy)
InterPro Domains

IPR021043 MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain
GlyGen

Q91VE6 1 site, 1 O-linked glycan (1 site)

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All nucleic 10

cDNA 10

Microarray probesets 4

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MGI:2138364

Summaries

All 33

Gene Ontology 4

Phenotypes 11
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nifk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8358	Chr1:118249564-118249612 (+)	19 bp
Tssr8359	Chr1:118249618-118249624 (+)	52 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24